TLR3 cascade

Stable Identifier
Gallus gallus
Related Species
Infectious bronchitis virus
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Toll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, and macrophages, and appears to play a central role in mediating both the antiviral and inflammatory responses of the innate immunity in combating viral infections.

Chicken TLR3 protein shows 61% identity to human TLR3.

The chicken ortholog of mammalian TLR3 specifically recognizes poly I:C, a dsRNA analogue, like its mammalian counterpart. In the chicken as in mammals, poly I:C rapidly induces type 1 IFN.

Literature References
PubMed ID Title Journal Year
19627256 Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins

O'Neill, LA, Carpenter, S

Biochem J 2009
18202435 Sensing of viral infection and activation of innate immunity by toll-like receptor 3

Beyaert, R, Staal, J, Vercammen, E

Clin Microbiol Rev 2008
18241342 Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss

Burt, DW, Berlin, S, Temperley, ND, Griffin, DK, Paton, IR

BMC Genomics 2008
17870162 Activation of the TLR3 pathway regulates IFNbeta production in chickens

Bean, AG, Lowenthal, JW, Karpala, AJ

Dev Comp Immunol 2008
15733829 Transcriptional signaling by double-stranded RNA: role of TLR3

Sarkar, SN, Sen, GC

Cytokine Growth Factor Rev 2005
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