TRAF6 binds to p-IRAK2 complexed with activated TLR

Stable Identifier
R-GGA-434053
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Salmonella typhimurium
Compartment
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There is little experimental data about mammalian IRAK2 mediated signaling. It is possible that phosphorylated IRAK2, like IRAK1, dissociates from upstream adapters such as MyD88 but leaves its interaction with the downstream adapter TRAF6 unaffected. Furthermore Keating et al. [2007] showed that IRAK2 can promote TRAF6 ubiquitination. Other studies [Wan et al 2009] detected IRAK2-TRAF6 interaction upon LPS stimulation.

In this reaction we assume that chicken IRAK2 behaves like its mammalian homolog IRAK2.

Literature References
PubMed ID Title Journal Year
18070982 TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB

Muroi, M, Tanamoto, K

J Leukoc Biol 2008
17878161 IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

Keating, SE, Maloney, GM, Moran, EM, Bowie, AG

J Biol Chem 2007
19224918 Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control

Wan, Y, Xiao, H, Affolter, J, Kim, TW, Bulek, K, Chaudhuri, S, Carlson, D, Hamilton, T, Mazumder, B, Stark, GR, Thomas, J, Li, X

J Biol Chem 2009
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