p-IRAK2- TRAF6 dissociates from the activated chTLR complex

Stable Identifier
R-GGA-434084
Type
Reaction [dissociation]
Species
Gallus gallus
Related Species
Salmonella typhimurium
Compartment
ReviewStatus
5/5
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There is little experimental data about mammalian IRAK2 mediated signaling. It is possible that phosphorylated IRAK2, like IRAK1, dissociates from upstream adapters such as MyD88 but leaves its interaction with the downstream adapter TRAF6 unaffected. Furthermore Keating et al. [2007] showed that IRAK2 can promote TRAF6 ubiquitination. Other studies [Wan et al 2009] detected IRAK2-TRAF6 interaction upon LPS stimulation.

In this reaction we assume that chicken IRAK2 behaves like its mammalian homolog IRAK2.

Literature References
PubMed ID Title Journal Year
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C

J Biol Chem 2004
19224918 Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control

Li, X, Wan, Y, Stark, GR, Thomas, J, Hamilton, T, Kim, TW, Xiao, H, Carlson, D, Chaudhuri, S, Bulek, K, Mazumder, B, Affolter, J

J Biol Chem 2009
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