NFkB activation mediated by RIP1 complexed with activated TLR3

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Gallus gallus
Related Species
Infectious bronchitis virus
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Receptor-interacting protein 1 (RIP1) mediates the activation of proinflammatory cytokines via intermediate induction of IKK complex in NFkB pathways [Ea et al. 2006]. Poly(I-C) treatment stimulated the recruitment of RIP1, TRAF6, and TAK1 to the TLR3 receptor complex in human embryonic kidney HEK293 transfected with FLAG-tagged TLR3 [Cusson-Hermance et al. 2005]. RIP1 was shown to be dispensable for TRIF-dependent activation of IRF3, which occurs in a TRIF/TBK1/IKKi-dependent manner [Cusson-Hermance et al. 2005, Sato et al. 2003]

Literature References
PubMed ID Title Journal Year
16115877 Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

Fitzgerald, KA, Cusson-Hermance, N, Khurana, S, Kelliher, MA, Lee, TH

J Biol Chem 2005
1533881 p105, the NF-kappa B p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells

Gilmore, TD, Chang, D, Mosialos, G, Capobianco, AJ

J Virol 1992
15064760 RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B

Blancheteau, V, Meylan, E, Burns, K, Kelliher, M, Tschopp, J, Martinon, F, Hofmann, K

Nat Immunol 2004
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