Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1

Stable Identifier
R-GGA-434136
Type
Pathway
Species
Gallus gallus
Related Species
Infectious bronchitis virus
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Summation

TBK1 and IKK epsilon(IKKi) are described as essential regulators of pathogen-triggered IFN gene activation through the direct phosphorylation of IFN regulatory factors.

Embryonic fibroblast cells from TBK1-deficient mice show decreased IRF3 activation and IFN induction by poly IC, while IKKi-deficient cells show normal IRF3 activation. However, the activation of IRF3 is totally abolished in TBK1 and IKKi double-deficient cells, indicating that the functions of TBK1 and IKKi are redundant in mouse embryo fibroblast cells.[Hemmi et al 2004].

TBK1/IKKi interact with SIKE (Suppressor of IKK epsilon), which was shown to act as an inhibitor of TBK1/IKKi-mediated type I IFN production, but not NF-kB activation signaling[Huang J et al 2005].

Literature References
PubMed ID Title Journal Year
14679297 IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

McWhirter, SM, Fitzgerald, KA, Rosains, J, Rowe, DC, Golenbock, DT, Maniatis, T

Proc Natl Acad Sci U S A 2004
17599067 Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes

Ikeda, F, Hecker, CM, Rozenknop, A, Nordmeier, RD, Rogov, V, Hofmann, K, Akira, S, Dötsch, V, Dikic, I

EMBO J 2007
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