Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1

Stable Identifier
R-GGA-434136
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Pathway
Species
Gallus gallus
Related Species
Infectious bronchitis virus
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TBK1 and IKK epsilon(IKKi) are described as essential regulators of pathogen-triggered IFN gene activation through the direct phosphorylation of IFN regulatory factors.

Embryonic fibroblast cells from TBK1-deficient mice show decreased IRF3 activation and IFN induction by poly IC, while IKKi-deficient cells show normal IRF3 activation. However, the activation of IRF3 is totally abolished in TBK1 and IKKi double-deficient cells, indicating that the functions of TBK1 and IKKi are redundant in mouse embryo fibroblast cells.[Hemmi et al 2004].

TBK1/IKKi interact with SIKE (Suppressor of IKK epsilon), which was shown to act as an inhibitor of TBK1/IKKi-mediated type I IFN production, but not NF-kB activation signaling[Huang J et al 2005].

Literature References
PubMed ID Title Journal Year
17599067 Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes

Dötsch, V, Rozenknop, A, Rogov, V, Nordmeier, RD, Ikeda, F, Akira, S, Dikic, I, Hecker, CM, Hofmann, K

EMBO J 2007
14679297 IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

Fitzgerald, KA, Rowe, DC, McWhirter, SM, Golenbock, DT, Maniatis, T, Rosains, J

Proc Natl Acad Sci U S A 2004
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