Reactome | MKK4 [cytosol]

MKK4 [cytosol]

Stable Identifier

R-GGA-437642

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

MAP2K4, SEK1, C-JUN N-terminal kinase kinase 1

Locations in the PathwayBrowser

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Innate Immune System (Gallus gallus)

- Toll-like receptors (TLR) cascades (Gallus gallus)
  - TLR15 cascade (Gallus gallus)
    - MyD88 cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        MKK4 [cytosol] (Gallus gallus)
  - TLR2 subfamily cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        MKK4 [cytosol] (Gallus gallus)
  - TLR21 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        MKK4 [cytosol] (Gallus gallus)
  - TLR3 cascade (Gallus gallus)
    - TRAF6 mediated induction of proinflammatory cytokines (Gallus gallus)
      - MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        MKK4 [cytosol] (Gallus gallus)
  - TLR4 cascade (Gallus gallus)
    - MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        MKK4 [cytosol] (Gallus gallus)
  - TLR5 cascade (Gallus gallus)
    - MyD88 cascade initiated on plasma membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        MKK4 [cytosol] (Gallus gallus)
  - TLR7 cascade (Gallus gallus)
    - MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
      - NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
        
        MAPK activation in TLR cascade (Gallus gallus)
        
        Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation (Gallus gallus)
        
        Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)
        
        MKK4 [cytosol] (Gallus gallus)

External Reference Information

External Reference

ENSEMBL:ENSGALP00000001475 MAP2K4

Gene Names

MAP2K4

Participates

as an input of

Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)

Other forms of this molecule

phosphorylated MKK4 [cytosol]