Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation

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R-GGA-437986
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Gallus gallus
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C-Jun NH2 terminal kinases are stress activated MAPKs, also known as SAPKs. The JNK pathway is activated by heat shock, or inflammatory cytokines, or UV radiation. The JNKs are encoded by at least three genes: JNK1/SAPK-gamma, JNK2/SAPK-alpha and JNK3/ SAPK-beta.

Activation of JNKs is mediated by activated TAK1 which phosphorylates two dual specificity enzymes MKK4 (MAPK kinase 4) and MKK7(MAPK kinase 7).

Literature References
PubMed ID Title Journal Year
11057897 Signal transduction by the JNK group of MAP kinases

Davis, RJ

Cell 2000
11460167 TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Deng, L, Inoue, J, Akkaraju, GR, Hong, M, Wang, C, Chen, ZJ

Nature 2001
12471242 Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

Lapadat, R, Johnson, GL

Science 2002
15837794 Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes

Kracht, M, Wolter, S, Resch, K, Dittrich-Breiholz, O, Wirth, D, Thiefes, A, Mushinski, JF, Luckow, B, Schneider, H, Graue, N, Dörrie, A, Hoffmann, E

J Biol Chem 2005
8533096 Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

Nishida, E, Shibuya, H, Shirakabe, K, Ueno, N, Oishi, I, Matsumoto, K, Yamaguchi, K, Irie, K, Taniguchi, T

Science 1995
16186825 Essential function for the kinase TAK1 in innate and adaptive immune responses

Kawai, T, Takeuchi, O, Sanjo, H, Takeda, K, Ninomiya-Tsuji, J, Sato, S, Yamamoto, M, Akira, S, Matsumoto, K

Nat Immunol 2005
9162092 Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.

Blank, JL, Deacon, K

J Biol Chem 1997
7839144 Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

Davis, RJ, Ulevitch, RJ, Wu, IH, Derijard, B, Han, J, Raingeaud, J, Barrett, T

Science 1995
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