Activated JNK migrates to the nucleoplasm

Stable Identifier
R-GGA-437995
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol, nucleoplasm, nuclear envelope
ReviewStatus
5/5
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Activated JNK migrates to the nucleoplasm
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Shortly after phosphorylation JNKs are translocated to nucleus where they associate and activate their target transcription factors.
Literature References
PubMed ID Title Journal Year
12193592 Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP)

Nimpf, J, Lutz, C, Enzinger, C, Baier-Bitterlich, G, Jenny, M, Boecklinger, K, Baier, G, Utermann, G

J Biol Chem 2002
9195981 A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.

Yoshida, K, Morimoto, S, Mizukami, Y, Yoshioka, K

J Biol Chem 1997
13130464 Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK

Boyle, DL, Sundarrajan, M, Chabaud-Riou, M, Firestein, GS, Hammaker, D

Arthritis Rheum 2003
Participants
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Output
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as an event of
Inferred From
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
Authored
Shamovsky, V  (2009-09-22)
Reviewed
D'Eustachio, P  (2010-05-23)
Created
Shamovsky, V  (2009-09-22)
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