MKK4 phosphorylates JNK

Stable Identifier
R-GGA-438005
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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Activated JNK kinases (MKK4 and MKK7) phosphorylate threonine and tyrosine residues in the characteristic Thr-Pro-Tyr phosphoacceptor loop of each JNK isoform.

Chicken JNK2(MAPK9) shows 98% identity with human JNK2 (UniProtKB sequence data using NCBI BLASTP 2.2.20). Multiple sequence alignment of the human, mouse and chicken JNK2 proteins by ClustalW showed that Thr183 and Tyr185 residues, that are responsible for the JNK activation in human, are identical for all three orthologs.

Other chicken JNK isoforms JNK1(MAPK8) and JNK3(MAPK10), whose existence is confirmed at the transcript level, share 99% and 95% amino-acid sequence identity with their human counterparts respectively.

Literature References
PubMed ID Title Journal Year
17875933 Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death

Wang, X, Jin, JW, Boot-Handford, RP, Tournier, C, Robinson, AC, Dajas-Bailador, F, Nadarajah, B, McColl, BW

Mol Cell Biol 2007
16186825 Essential function for the kinase TAK1 in innate and adaptive immune responses

Kawai, T, Takeuchi, O, Sanjo, H, Takeda, K, Ninomiya-Tsuji, J, Sato, S, Yamamoto, M, Akira, S, Matsumoto, K

Nat Immunol 2005
Participants
Participates
Catalyst Activity

protein serine/threonine/tyrosine kinase activity of phosphorylated MKK4 [cytosol]

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