Activation and dimerization of c-JUN in the nucleus

Stable Identifier
R-GGA-438026
Type
Reaction [transition]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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Activation and dimerization of c-JUN in the nucleus
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Shortly after phosphorylation JNKs are translocated to nucleus where they associate and activate their target transcription factors.
Literature References
PubMed ID Title Journal Year
18793328 c-Jun expression, activation and function in neural cell death, inflammation and repair

Raivich, G

J Neurochem 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

JUN kinase activity of phosphorylated JNK homologs [nucleoplasm]

Physical Entity
phosphorylated JNK homologs [nucleoplasm] (Gallus gallus)
Activity
JUN kinase activity (GO:0004705)
This event is regulated
Negatively by
Regulator
MAPK phosphatases [nucleoplasm] (Gallus gallus)
Inferred From
Activated JNKs phosphorylate c-JUN (Homo sapiens)
Authored
Shamovsky, V  (2009-09-22)
Reviewed
D'Eustachio, P  (2010-05-23)
Created
Shamovsky, V  (2009-09-22)
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