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VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane]
Stable Identifier
R-GGA-4420164
Type
Complex
Species
Gallus gallus
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
CRK binds BCAR1 and or PXN (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
DOCK180:ELMO binds CRK (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
HSP90AA1 binds p-6Y-VEGFR2 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
PTK2 autophosphorylates (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
PXN binds p-6Y,S732-PTK2 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
SRC-1 binds p-Y397-PTK2 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
SRC-1 phosphorylates PTK2-beta (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
SRC-1 phosphorylates SHB (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
SRC-1 phosphorylates p-Y397-PTK2 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
Src kinases phosphorylate VAV (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
phospho-SHB [cytosol]
(Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane]
(Gallus gallus)
Participates
as a component of
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane] (Gallus gallus)
as an input of
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)
as an output of
SRC-1 phosphorylates SHB (Gallus gallus)
Inferred From
VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane]
(Homo sapiens)
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