Cis-heterodimerization of NgCAM and Axonin-1

Stable Identifier
Reaction [binding]
Gallus gallus
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By analogy to the well-studied chicken system, L1 can be coexpressed with axonin-1 (TAG-1/Contactin-2) on same growth cone membrane and the two proteins form a cis-heterodimer required for neurite growth.

Literature References
PubMed ID Title Journal Year
8978825 Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion

Buchstaller, A, Kunz, S, Berger, P, Kunz, B, Ziegler, U, Rader, C, Sonderegger, P

J Cell Biol 1996
9837910 Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesion

Malhotra, JD, Tsiotra, P, Karagogeos, D, Hortsch, M

J Biol Chem 1998
12139915 Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members

Pavlou, O, Theodorakis, K, Falk, J, Kutsche, M, Schachner, M, Faivre-Sarrailh, C, Karagogeos, D

Mol Cell Neurosci 2002
Orthologous Events