Reactome | Activated TLR7 or 21 recruits MyD88

Activated TLR7 or 21 recruits MyD88

Stable Identifier

R-GGA-451439

Type

Reaction [binding]

Species

Gallus gallus

Compartment

endosome membrane, cytosol

ReviewStatus

5/5

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Cloning and analysis of full length chicken MyD88 revealed an open reading frame which encodes a predicted protein sequence of 368 amino acids (aa). Two more chicken MyD88 isoforms with 299 and 376 residues are described in the literature [Qiu Y et al 2008, Lynn et al 2003]. The amino acid sequences of the chMyD88 368 and 376 residue isoforms are 99% identical, 97% identical to the 299 aa chMyD88 predicted peptide and 68% identical to human MyD88 (296 aa).

Chicken MyD88 is recruited to the activated hetero or homodimer of chTLR that is located either on plasma membrane (TLR4, TLR2/1, TLR5 and TLR15) or endosome membrane (TLR7 and TLR21).

Literature References

PubMed ID	Title	Journal	Year
17676477	Molecular cloning and expression analysis of chicken MyD88 and TRIF genes Brisbin, JT, Lambourne, MD, Sharif, S, Mayameei, A, Sarson, AJ, Wheaton, S	DNA Seq	2007
18582498	Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88) Shen, Y, Ma, Z, Qiu, Y, Li, X, Ding, C	Dev Comp Immunol	2008