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activated TLR7/ or TLR21 : MyD88 complex [endosome membrane]
Stable Identifier
R-GGA-451459
Type
Complex
Species
Gallus gallus
Compartment
endosome membrane
Locations in the PathwayBrowser
Expand all
Innate Immune System (Gallus gallus)
Toll-like receptors (TLR) cascades (Gallus gallus)
TLR21 cascade (Gallus gallus)
MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
Activated TLR7 or 21 recruits MyD88 (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex. (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
Activated TAK1 leaves endosome membrane (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [cytosol] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Activated TRAF6 synthesizes free K63 linked pUb chains (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Autoubiquitination of oligoTRAF6 bound to p-IRAK2 (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
TLR7 cascade (Gallus gallus)
MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)
Activated TLR7 or 21 recruits MyD88 (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex. (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation (Gallus gallus)
Activated TAK1 leaves endosome membrane (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [cytosol] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Activated TRAF6 synthesizes free K63 linked pUb chains (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)
p-IRAK2: pUb_oligo TRAF6 : phospho TAK1 :TAB1 : TAB2/TAB3 : K63linked free pUb chain [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
p-IRAK2:oligo pUb TRAF6 : TAK1 :TAB1 : TAB2/TAB3 : free K63 pUb chains [endosome membrane] (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Autoubiquitination of oligoTRAF6 bound to p-IRAK2 (Gallus gallus)
oligo pUb-TRAF6 : p-IRAK2 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)
TRAF6 bound to activated TLR7 or 21 [endosome membrane] (Gallus gallus)
p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] (Gallus gallus)
Participants
components
activated TLR7 or 21 bound to ligand [endosome membrane]
(Gallus gallus)
x 2
MyD88 [endosome membrane]
(Gallus gallus)
Participates
as an output of
Activated TLR7 or 21 recruits MyD88 (Gallus gallus)
as a component of
activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] (Gallus gallus)
activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] (Gallus gallus)
as an input of
IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)
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