TLR7 binds to recognized ligands

Stable Identifier
R-GGA-451481
Type
Reaction [binding]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
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Strong up-regulation of IL-1beta but not type 1 interferons was reported in TLR7-expressing chicken HD11 cells and splenocytes upon stimulation with R828 or loxoribine [Phiblin et al 2005]. Moreover, chTLR7 activation was shown to be chloroquine-sensitive, suggesting that TLR7 signaling requires endosomal acidification, as for mammalian TLR7.
Literature References
PubMed ID Title Journal Year
15804288 Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens

Smith, AL, Boyd, Y, Bumstead, N, Beal, RK, Goodchild, MJ, Young, J, Iqbal, M, Philbin, VJ

Immunology 2005
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