TLR7 cascade

Stable Identifier
R-GGA-451498
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Pathway
Species
Gallus gallus
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In mammals, TLR7 and TLR8 belong to TLR9 subfamily and senses RNA in endosomal compartments, initiating the MyD88 signaling cascade.

Although functional assays showed that chicken cells respond to known mammalian TLR7 and TLR9 ligands in vitro and in ovo [Philbin et al 2005, Jenkins KA et al 2009], bioinformatics analysis of the chicken genome have identified a disrupted ortholog of TLR8 and no direct ortholog of TLR9. Only TLR7 gene was found intact[Philbin et al 2005, Temperley ND et al 2008].The chicken TLR7 (chTLR7) amino acid sequence shows 62% identity to its human counterpart. chTLR7 mRNA was detected in immune-related tissues - spleen, caecal tonsil [Iqbal et al 2005, Phiblin et al 2005]. Chicken leukocytes, heterophils, monocytes and the chicken macrophage cell line HD11 have been also shown to express chTLR7 [Philbin et al 2005].

Literature References
PubMed ID Title Journal Year
18241342 Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss

Burt, DW, Berlin, S, Temperley, ND, Griffin, DK, Paton, IR

BMC Genomics 2008
15804288 Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens

Smith, AL, Boyd, Y, Bumstead, N, Beal, RK, Goodchild, MJ, Young, J, Iqbal, M, Philbin, VJ

Immunology 2005
15936435 Expression and function of Toll-like receptors in chicken heterophils

Smith, A, Philbin, V, Kogut, MH, Kaiser, P, He, H, Iqbal, M

Dev Comp Immunol 2005
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