TLR5 cascade

Stable Identifier
R-GGA-451534
Type
Pathway
Species
Gallus gallus
Related Species
Salmonella typhimurium
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In mammals, the interaction of flagellin with TLR5 induces a signaling cascade that utilizes MyD88 adaptor, IRAK family members, and downstream signaling mediators such as MAP kinases and NF-kB that regulate pro-inflammatory genes [Smith KD et al 2003].

The chicken tlr5 gene was cloned from the chicken NCSU macrophage cell line; It encodes a protein of 861 amino acids. The cloned chTLR5 showed 69% and 68% overall amino acid similarity to human and murine TLR5, respectively (Keestra AM et al, 2008). Chicken TLR5 mRNA is expressed in a broad range of tissues, immune cell subsets and chicken cell lines. The strongest signal was detected in colon, spleen, kidney, lung, heart, and testes (Iqbal M et al, 2005).

Comparisons of gene structure, genomic location, amino acid composition, and patterns of leucine-rich regions (LRR) consistent with the suggestion that chTLR5 is an orthologue of mammalian TLR5. Like its mammalian counterpart chTLR5 was reported to respond to bacterial flagellin (Iqbal M et al., 2005 and Keestra AM et al.,2008).

Literature References
PubMed ID Title Journal Year
18669607 Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways

Kogut, MH, Genovese, KJ, Kaiser, P, He, H

Innate Immun 2008
17045653 Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1

Kogut, MH, Genovese, KJ, He, H

Mol Immunol 2007
15784580 Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium

Smith, AL, Boyd, Y, Beal, RK, Maskell, DJ, Barrow, P, Wigley, P, Iqbal, M, McConnell, I, Bumstead, N, Withanage, GS, Goodchild, MJ, Young, J, Philbin, VJ

Infect Immun 2005
17964652 Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin

Keestra, AM, de Zoete, MR, van Aubel, RA, van Putten, JP

Mol Immunol 2008
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