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phospho-NFKB1 [cytosol]
Stable Identifier
R-GGA-451619
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
3xUb-p-S927,S932-NFKB1(1-968), Q04861
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-1 family signaling (Gallus gallus)
Interleukin-1 signaling (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
Interleukin-17 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
MAP kinase activation (Gallus gallus)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Gallus gallus)
3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Gallus gallus)
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
phospho-NFKB1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q04861 NFKB1
Gene Names
NFKB1
Chain
chain:1-983, chain:1-
Reference Genes
BioGPS Gene:396033 NFKB1
KEGG Gene (Gallus gallus):396033 NFKB1
Monarch:396033 NFKB1
NCBI Gene:396033 NFKB1
Reference Transcript
RefSeq:XM_015285415.1 NFKB1
RefSeq:NM_205134.1 NFKB1
Participates
as a component of
3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Gallus gallus)
This entity regulates
Negatively
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex
(Gallus gallus)
Other forms of this molecule
NFKB1 [specific granule lumen]
NFKB1 [extracellular region]
NFKB1 [secretory granule lumen]
NFkB1_p50 [nucleoplasm]
NFkB1_p50 [cytosol]
NFKB1 [cytosol]
NFKB1 [nucleoplasm]
NFKB1 [cytosol]
phospho-NFKB1 [cytosol]
Inferred From
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 927 (in Homo sapiens)
Coordinate
927
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 932 (in Homo sapiens)
Coordinate
932
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_990465.1
,
XP_015140901.1
OpenTargets
ENSG00000109320
PRO
Q04861
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