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IAP3 [cytosol]
Stable Identifier
R-GGA-50849
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
XIAP, Q8UVF8
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Gallus gallus)
Apoptosis (Gallus gallus)
Intrinsic Pathway for Apoptosis (Gallus gallus)
Apoptotic factor-mediated response (Gallus gallus)
Cytochrome c-mediated apoptotic response (Gallus gallus)
Activation of caspases through apoptosome-mediated cleavage (Gallus gallus)
Cleavage of Procaspase-3 by the apoptosome (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
Formation of apoptosome (Gallus gallus)
Regulation of the apoptosome activity (Gallus gallus)
XIAP binds CASP9 (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
XIAP:apoptosome [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
SMAC, XIAP-regulated apoptotic response (Gallus gallus)
SEPT4 binds XIAP (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
SEPT4 dimer:XIAP [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
SMAC (DIABLO) binds to IAPs (Gallus gallus)
SMAC (DIABLO) binds XIAP (Gallus gallus)
DIABLO dimer:XIAP [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
SMAC binds XIAP:Caspase-7 (Gallus gallus)
DIABLO:XIAP:Caspase-7 [cytosol] (Gallus gallus)
XIAP:Caspase-7 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
XIAP:Caspase-7 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (Gallus gallus)
Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Gallus gallus)
DIABLO dimer:XIAP [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
DIABLO:XIAP:Caspase-7 [cytosol] (Gallus gallus)
XIAP:Caspase-7 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
XIAP binds CASP3 (Gallus gallus)
DIABLO:XIAP:Caspase-3 [cytosol] (Gallus gallus)
XIAP:Caspase-3 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
XIAP:Caspase-3 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
XIAP binds CASP7 (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
XIAP:Caspase-7 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
Regulated Necrosis (Gallus gallus)
RIPK1-mediated regulated necrosis (Gallus gallus)
Regulation of necroptotic cell death (Gallus gallus)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
TNF signaling (Gallus gallus)
Regulation of TNFR1 signaling (Gallus gallus)
K63polyUb-RIPK1 is deubiquitinated (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Gallus gallus)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Gallus gallus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Gallus gallus)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Gallus gallus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TNFR1-induced NF-kappa-B signaling pathway (Gallus gallus)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
PTEN Regulation (Gallus gallus)
Regulation of PTEN localization (Gallus gallus)
PTEN undergoes monoubiquitination (Gallus gallus)
XIAP,NEDD4 [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
Regulation of PTEN stability and activity (Gallus gallus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Gallus gallus)
IAP3 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q8UVF8
Gene Names
IAP3
Reference Genes
BioGPS Gene:395280 IAP3
ENSEMBL:ENSGALG00000008491
KEGG Gene (Gallus gallus):395280 IAP3
Monarch:395280 IAP3
NCBI Gene:395280 IAP3
Reference Transcript
RefSeq:XM_015278182.1 IAP3
RefSeq:NM_204588.2 IAP3
RefSeq:XM_015278183.1 IAP3
Participates
as a member of
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Gallus gallus)
as a candidate of
XIAP,NEDD4 [cytosol] (Gallus gallus)
BIRC2,3,4 [cytosol] (Gallus gallus)
as an input of
SEPT4 binds XIAP (Gallus gallus)
SMAC (DIABLO) binds XIAP (Gallus gallus)
XIAP binds CASP3 (Gallus gallus)
XIAP binds CASP7 (Gallus gallus)
XIAP binds CASP9 (Gallus gallus)
as a component of
SEPT4 dimer:XIAP [cytosol] (Gallus gallus)
XIAP:apoptosome [cytosol] (Gallus gallus)
XIAP:Caspase-7 [cytosol] (Gallus gallus)
DIABLO dimer:XIAP [cytosol] (Gallus gallus)
XIAP:Caspase-3 [cytosol] (Gallus gallus)
This entity regulates
Negatively
Cleavage of Procaspase-7 by the apoptosome
(Gallus gallus)
Cleavage of Procaspase-3 by the apoptosome
(Gallus gallus)
Other forms of this molecule
IAP3 [nucleoplasm]
IAP3 [cytosol]
Inferred From
XIAP [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_015133668.1
,
NP_989919.1
,
XP_015133669.1
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