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phospho-RAF1 [plasma membrane]
Stable Identifier
R-GGA-5672665
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
p-S338,Y341,T491,S494,S621 RAF1, P05625
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
activated RAF/KSR1 [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
Negative regulation of MAPK pathway (Gallus gallus)
Negative feedback regulation of MAPK pathway (Gallus gallus)
Activated MAPK phosphorylates RAF1 (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
PEBP1 binds activated RAF1 (Gallus gallus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Gallus gallus)
phospho-RAF1 [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:P05625
Gene Names
RAF1
Reference Genes
BioGPS Gene:396245 RAF1
ENSEMBL:ENSGALG00000004998
KEGG Gene (Gallus gallus):396245 RAF1
Monarch:396245 RAF1
NCBI Gene:396245 RAF1
Reference Transcript
RefSeq:XM_015293013.1 RAF1
RefSeq:XM_015293009.1 RAF1
RefSeq:XM_015293010.1 RAF1
RefSeq:XM_015293012.1 RAF1
RefSeq:NM_205307.2 RAF1
RefSeq:XM_015293011.1 RAF1
Other Identifiers
396245
GO:0000166
GO:0000186
GO:0001678
GO:0001934
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005794
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0007010
GO:0007165
GO:0007190
GO:0007267
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009058
GO:0015031
GO:0016020
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0017016
GO:0019899
GO:0022607
GO:0030154
GO:0030878
GO:0031143
GO:0031333
GO:0033138
GO:0034641
GO:0035019
GO:0035556
GO:0035773
GO:0035994
GO:0042592
GO:0042802
GO:0043066
GO:0043167
GO:0043226
GO:0045104
GO:0045944
GO:0046872
GO:0048011
GO:0048538
GO:0048856
GO:0060324
GO:0065003
GO:0071550
GO:1902042
GT_A_87_P131613
GT_A_87_P139518
GT_A_87_P194458
Gga.685.1.S1_at
Gga.685.1.S2_at
Participant Of
input
Activated MAPK phosphorylates RAF1
hasComponent
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
hasMember
activated RAF/KSR1 [plasma membrane]
Other forms of this molecule
RAF1 [cytosol]
phospho-RAF1 [cytosol]
phospho-RAF1 [cytosol]
phospho-RAF1 [cytosol]
phospho-RAF1 [plasma membrane]
phospho-RAF1 [plasma membrane]
phospho-RAF1 [plasma membrane]
phospho-RAF1 [cytosol]
phospho-RAF1 [cytosol]
Inferred From
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 621 (in Homo sapiens)
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341 (in Homo sapiens)
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 338 (in Homo sapiens)
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 491 (in Homo sapiens)
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494 (in Homo sapiens)
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_015148498.1
,
NP_990638.1
,
XP_015148499.1
,
XP_015148496.1
,
XP_015148495.1
,
XP_015148497.1
OpenTargets
ENSG00000132155
IntEnz
2.7.11.1
Ensembl
ENSGALP00000046736
,
ENSGALG00000004998
,
ENSGALP00000051230
,
ENSGALT00000055408
,
ENSGALT00000049372
PRO
P05625
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