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phospho-p-S446,S729-BRAF [cytosol]
Stable Identifier
R-GGA-5672673
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
Q04982
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
MAP2K and MAPK activation (Gallus gallus)
Dissociation of RAS:RAF complex (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
MAP2Ks phosphorylate MAPKs (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
RAF phosphorylates MAP2K dimer (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Gallus gallus)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Gallus gallus)
dephosphorylated inactive RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAF:YWHAB dimer [cytosol] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Gallus gallus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
Negative regulation of MAPK pathway (Gallus gallus)
PEBP1 binds activated RAF1 (Gallus gallus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Gallus gallus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
RAF activation (Gallus gallus)
"Activator" RAF:YWHAB dimer binds RAS:GTP (Gallus gallus)
'activator' RAF:YWHAB dimer [cytosol] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAF:YWHAB dimer [cytosol] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Gallus gallus)
dephosphorylated inactive RAFS:YWHAB dimer [cytosol] (Gallus gallus)
dephosphorylated inactive RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
Phosphorylation of RAF (Gallus gallus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Gallus gallus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Gallus gallus)
dephosphorylated inactive RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAF:YWHAB dimer [cytosol] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Gallus gallus)
dephosphorylated inactive RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAF:YWHAB dimer [cytosol] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Gallus gallus)
dephosphorylated inactive RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAF:YWHAB dimer [cytosol] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
Raf dimer inhibitors bind RAF heterodimers (Gallus gallus)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Gallus gallus)
dephosphorylated inactive RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAF:YWHAB dimer [cytosol] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Gallus gallus)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Gallus gallus)
dephosphorylated inactive RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Gallus gallus)
'activator' RAF:YWHAB dimer [cytosol] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
YWHAB dimer dissociates from dephosphorylated RAF (Gallus gallus)
dephosphorylated inactive RAFS:YWHAB dimer [cytosol] (Gallus gallus)
dephosphorylated inactive RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
dephosphorylated inactive RAFs [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
Signalling to ERKs (Gallus gallus)
Prolonged ERK activation events (Gallus gallus)
Frs2-mediated activation (Gallus gallus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Gallus gallus)
BRAF dimer complex [cytosol] (Gallus gallus)
B-Raf complex [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
BRAF autophosphorylates downstream of RAP1 and NGF (Gallus gallus)
BRAF dimer complex [cytosol] (Gallus gallus)
B-Raf complex [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
RAP1:GTP:B-Raf complex [endosome membrane] (Gallus gallus)
BRAF dimer complex [cytosol] (Gallus gallus)
B-Raf complex [cytosol] (Gallus gallus)
phospho-p-S446,S729-BRAF [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q04982
Reference Genes
BioGPS Gene:396239
ENSEMBL:ENSGALG00000012865
KEGG Gene (Gallus gallus):396239
Monarch:396239
NCBI Gene:396239
Reference Transcript
RefSeq:XM_015284532.1
RefSeq:NM_205302.1
Participates
as a component of
B-Raf complex [cytosol] (Gallus gallus)
as a member of
dephosphorylated inactive RAFs [cytosol] (Gallus gallus)
'activator' RAFs [cytosol] (Gallus gallus)
Other forms of this molecule
BRAF [cytosol]
phospho-hyperphosphorylated BRAF [plasma membrane]
phospho-p-S365,S446,S729 BRAF [cytosol]
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane]
phospho-p-S446,T599,S602,S729 BRAF [cytosol]
Inferred From
p-S446,S729-BRAF [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 446 (in Homo sapiens)
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729 (in Homo sapiens)
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_990633.1
,
XP_015140018.1
PRO
Q04982
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