Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex.

Stable Identifier
R-GGA-571316
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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General
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Chicken IRAK4 shows 66% amino acid identity to human IRAK4. It is assumed here that chicken IRAK4 is activated by autophosphorylation like its human homologue.

Literature References
PubMed ID Title Journal Year
18438411 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Kumagai, Y, Kawai, T, Takeuchi, O, Saitoh, T, Matsushita, K, Sato, S, Akira, S, Matsui, K, Kato, H, Kawagoe, T

Nat Immunol 2008
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C

J Biol Chem 2004
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane]

Inferred From
Authored
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Created
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