Reactome | NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation

NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation

Stable Identifier

R-GGA-573298

Type

Pathway

Species

Gallus gallus

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation

Click the image above or here to open this pathway in the Pathway Browser

Expression of chicken TLR21 in HEK293 was shown to upregulate NF-kB activation in response to synthetic CpG DNA (Keestra et al 2010). PKC, MEK1/2, p38MAPK and NF-kB signaling pathways were also reported to mediate nitric oxide production by avian HD11 macrophage cells in response to CpG DNA. (He H and Kogut MH 2003).

Literature References

PubMed ID	Title	Journal	Year
12873704	CpG-ODN-induced nitric oxide production is mediated through clathrin-dependent endocytosis, endosomal maturation, and activation of PKC, MEK1/2 and p38 MAPK, and NF-kappaB pathways in avian macrophage cells (HD11) Kogut, MH, He, H	Cell Signal	2003
20498358	Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9 Keestra, AM, de Zoete, MR, Bouwman, LI, van Putten, JP	J Immunol	2010

Participants

Events

Participates

as an event of

MyD88-dependent cascade initiated on endosome membrane (Gallus gallus)

Authored

Shamovsky, V (2010-11-30)

Reviewed

D'Eustachio, P (2010-12-06)

Created

Shamovsky, V (2010-04-09)

Cite Us!