Reactome | NDUFS8 [mitochondrial matrix]

NDUFS8 [mitochondrial matrix]

Stable Identifier

R-GGA-6788526

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

mitochondrial matrix

Synonyms

NDUFS8, A0A1D5PE41

Locations in the PathwayBrowser

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Metabolism (Gallus gallus)

- Aerobic respiration and respiratory electron transport (Gallus gallus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Gallus gallus)
    - Respiratory electron transport (Gallus gallus)
      - Complex I biogenesis (Gallus gallus)
        
        IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        Intermediate 2 [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Gallus gallus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 2 [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        Intermediate 2 [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Gallus gallus)
        
        550kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 2 [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        815kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        550kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 2 [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        NDUF subunits bind to form the IP subcomplex (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        NUBPL transfers 4Fe-4S to Complex I subunits (Gallus gallus)
        
        NDUF subunits [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        NDUF:4Fe-4S subunits [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Gallus gallus)
        
        815kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        550kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 2 [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        980kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        815kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        550kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 2 [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Gallus gallus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 2 [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        550kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 2 [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Gallus gallus)
        
        980kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        815kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        550kDa complex [mitochondrial inner membrane] (Gallus gallus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 2 [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 [mitochondrial inner membrane] (Gallus gallus)
        
        IP subcomplex [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
        
        Complex I [mitochondrial inner membrane] (Gallus gallus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Gallus gallus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Gallus gallus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Gallus gallus)
        
        Complex I [mitochondrial inner membrane] (Gallus gallus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Gallus gallus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Gallus gallus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Gallus gallus)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Gallus gallus)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)
        
        NDUFS8 [mitochondrial matrix] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5PE41

Gene Names

NDUFS8

Reference Genes

BioGPS Gene:769492 NDUFS8

ENSEMBL:ENSGALG00000040173

ENSEMBL:ENSGALG00010021238.1 NDUFS8

KEGG Gene (Gallus gallus):769492 NDUFS8

Monarch:769492 NDUFS8

NCBI Gene:769492 NDUFS8

Reference Transcript

RefSeq:XM_001232779.4 NDUFS8

Other Identifiers

769492

GO:0003824

GO:0003954

GO:0005739

GO:0005747

GO:0006091

GO:0006120

GO:0007005

GO:0016020

GO:0016491

GO:0016651

GO:0032981

GO:0043226

GO:0051539

GO:0065003

GT_A_87_P022995

Gga.7874.1.S1_at

Participates

as a member of

NDUF subunits [mitochondrial matrix] (Gallus gallus)

as a component of

NDUFS8:2x4Fe-4S [mitochondrial matrix] (Gallus gallus)

Inferred From

NDUFS8 [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

XP_001232780.1

OpenTargets

ENSG00000110717

Ensembl

ENSGALT00010051476, ENSGALP00010030667, ENSGALG00010021238

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