Reactome | VAMP2 [clathrin-coated endocytic vesicle membrane]

VAMP2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-GGA-8869129

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

VAMP2, A0A1D5PLR5

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5PLR5

Gene Names

VAMP2

Reference Genes

ENSEMBL:ENSGALG00000030350

Other Identifiers

424827

GO:0003674

GO:0005484

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0006810

GO:0006906

GO:0008150

GO:0016020

GO:0016021

GO:0016192

GO:0017075

GO:0019905

GO:0022607

GO:0030674

GO:0031201

GO:0032991

GO:0035493

GO:0061024

GO:0065003

Participant Of

hasMember

VAMP2,3,8 [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

VAMP2 [secretory granule membrane]

VAMP2 [cytoplasmic vesicle membrane]

VAMP2 [Golgi membrane]

VAMP2 [lysosomal membrane]

VAMP2 [cytosol]

VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]

VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

VAMP2 [plasma membrane]

VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]

Inferred From

VAMP2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000220205

Ensembl

ENSGALP00000053785, ENSGALG00000030350, ENSGALT00000082865

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