Reactome | VAMP7 [clathrin-coated endocytic vesicle membrane]

VAMP7 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-GGA-8869135

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

VAMP7, Q5ZL74

Locations in the PathwayBrowser

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Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q5ZL74

Gene Names

VAMP7

Reference Genes

BioGPS Gene:422297 VAMP7

ENSEMBL:ENSGALG00000007476

KEGG Gene (Gallus gallus):422297 VAMP7

Monarch:422297 VAMP7

NCBI Gene:422297 VAMP7

Reference Transcript

Participates

as a component of

AGFG1:VAMP7 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

Other forms of this molecule

VAMP7 [cytoplasmic vesicle membrane]

VAMP7 [Golgi membrane]

VAMP7 [plasma membrane]

VAMP7 [lysosomal membrane]

VAMP7 [late endosome membrane]

Inferred From

VAMP7 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_015133771.1, XP_015133775.1, NP_001026292.1, XP_015133774.1, XP_015133772.1, XP_015133773.1

OpenTargets

ENSG00000124333

PRO

Q5ZL74

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