Reactome | phospho-p-Y-GAB2 [cytosol]

phospho-p-Y-GAB2 [cytosol]

Stable Identifier

R-GGA-912529

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

A0A3Q2UDN3

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Cytokine Signaling in Immune system (Gallus gallus)
  - FLT3 Signaling (Gallus gallus)
    - Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Gallus gallus)
      - Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
      - Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Gallus gallus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
  - Signaling by Interleukins (Gallus gallus)
    - Interleukin-2 family signaling (Gallus gallus)
      - Interleukin receptor SHC signaling (Gallus gallus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
      - Interleukin receptor SHC signaling (Gallus gallus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Gallus gallus)
        
        GRB2:p-Y-GAB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y-GAB2 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q2UDN3

Reference Genes

ENSEMBL:ENSGALG00000054619

Participates

as a component of

Other forms of this molecule

phospho-p-Y643-GAB2 [cytosol]

phospho-p-5Y-GAB2 [cytosol]

GAB2 [cytosol]

phospho-p-Y452,Y476,Y584-GAB2 [cytosol]

Inferred From

p-Y-GAB2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

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