Reactome | ATP6V1A [cytosol]

ATP6V1A [cytosol]

Stable Identifier

R-GGA-912602

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

ATP6V1A, F1NBW2

Locations in the PathwayBrowser

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Cellular responses to stimuli (Gallus gallus)

- Cellular responses to stress (Gallus gallus)
  - Cellular response to starvation (Gallus gallus)
    - Amino acids regulate mTORC1 (Gallus gallus)
      - RRAGA,B exchanges GDP for GTP (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
      - RRAGA,B hydrolyzes GTP (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
      - RRAGC,D exchanges GTP for GDP (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
      - RRAGC,D hydrolyzes GTP (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
      - mTORC1 binds RHEB:GTP (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Gallus gallus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Gallus gallus)
        
        v-ATPase [lysosomal membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by Insulin receptor (Gallus gallus)
    - Insulin receptor recycling (Gallus gallus)
      - Endosome acidification (Gallus gallus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Gallus gallus)
        
        V-ATPase [endosome membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)

Transport of small molecules (Gallus gallus)

- Iron uptake and transport (Gallus gallus)
  - Transferrin endocytosis and recycling (Gallus gallus)
    - Acidification of Tf:TfR1 containing endosome (Gallus gallus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Gallus gallus)
        
        V-ATPase [endosome membrane] (Gallus gallus)
        
        ATP6V1 [cytosol] (Gallus gallus)
        
        ATP6V1A trimer [cytosol] (Gallus gallus)
        
        ATP6V1A [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:F1NBW2

Gene Names

ATP6V1A

Reference Genes

BioGPS Gene:395821 ATP6V1A

ENSEMBL:ENSGALG00000014800

ENSEMBL:ENSGALG00010022478.1 ATP6V1A

Monarch:395821 ATP6V1A

NCBI Gene:395821 ATP6V1A

Reference Transcript

Other Identifiers

395821

GO:0000166

GO:0000221

GO:0003824

GO:0005215

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005773

GO:0005829

GO:0005886

GO:0005902

GO:0006811

GO:0006879

GO:0015986

GO:0016020

GO:0016192

GO:0016324

GO:0016787

GO:0016874

GO:0016887

GO:0030141

GO:0031410

GO:0033176

GO:0033180

GO:0036295

GO:0043226

GO:0043231

GO:0046034

GO:0046933

GO:0046961

GO:0055065

GO:0055085

GO:0055086

GO:0097401

GO:0098793

GO:0140657

GO:1901135

GO:1902495

GO:1902600

GO:1904949

GT_A_87_P009125

GT_A_87_P012502

GT_A_87_P108608

GT_A_87_P131023

GT_A_87_P261528

GT_A_87_P307213

GT_A_87_P312322

GT_Sp_Chicken_BG641751_334

GT_Sp_Chicken_CN221032_2791

GT_Xhyb_Chicken_CN217402_654

Gga.1712.1.S1_a_at

Gga.1712.2.S1_a_at

Participates

as a component of

ATP6V1A trimer [cytosol] (Gallus gallus)

Inferred From

ATP6V1A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015149961.1, XP_015149949.1, XP_015149956.1

OpenTargets

ENSG00000114573

Ensembl

ENSGALP00010033050, ENSGALT00010054696, ENSGALG00010022478

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