Cbl binds B-cell linker protein

Stable Identifier
R-GGA-912730
Type
Reaction [binding]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Cbl binds B-cell linker protein
Cbl binds B-cell linker protein, a molecular scaffold bridging Syk to downstream signaling pathways by recruiting signaling molecules, such as Btk, phospholipase C gamma 2, Vav, and Grb2 to the cell membrane to form a signalosome complex. Cbl is believed to negatively regulate signaling from this complex. Consistent with this, Cbl inactivation reverses a number of critical defects in early B cell differentiation seen in BLNK-deficient mice (Song et al. 2007).
Literature References
PubMed ID Title Journal Year
10684856 Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding

Yamamoto, T, Hironaka, K, Kurosaki, M, Maeda, A, Tezuka, T, Kurosaki, T, Yasuda, T

J Exp Med 2000
Participants
Orthologous Events
Authored
Created
Cite Us!