Expression of ZIC1 in the neural plate border

Stable Identifier
R-GGA-9835290
Type
Reaction [omitted]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of ZIC1 in the neural plate border
During gastrulation (HH stage 4), ZIC1 is expressed in neural plate, neural plate border, and anterior epiblast (Khudyakov and Bronner-Fraser 2009). ZIC1 is maintained in the neural plate and is upregulated in the anterior neural folds (Khudyakov and Bronner-Fraser 2009, Williams et al. 2022). TFAP2A is required for expression of ZIC1 in the neural plate border (Rothstein and Simoes-Costa 2020). SOX2 and POU5F3 (OCT4) bind downstream of the ZIC1 coding region, may interact with TFAP2A, and activate ZIC1 expression (Hovland et al. 2022).
Literature References
PubMed ID Title Journal Year
19235729 Comprehensive spatiotemporal analysis of early chick neural crest network genes

Khudyakov, J, Bronner-Fraser, M

Dev Dyn 2009
35088714 Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

Williams, RM, Lukoseviciute, M, Sauka-Spengler, T, Bronner, ME

Elife 2022
36182685 Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells

Hovland, AS, Bhattacharya, D, Azambuja, AP, Pramio, D, Copeland, J, Rothstein, M, Simoes-Costa, M

Dev Cell 2022
31848212 Heterodimerization of TFAP2 pioneer factors drives epigenomic remodeling during neural crest specification

Rothstein, M, Simoes-Costa, M

Genome Res 2020
Participants
Input
Output
This event is regulated
Positively by
Regulator
TFAP2A [nucleoplasm] (Gallus gallus)
Regulator
POU5F3:SOX2:ZIC1 gene [nucleoplasm] (Gallus gallus)
Active Unit
POU5F3 [nucleoplasm]
SOX2 [nucleoplasm]
Orthologous Events
Expression of ZIC1 in the neural plate border (Homo sapiens)
Authored
May, B  (2023-05-12)
Reviewed
Gunhaga, L  (2023-10-28)
Patthey, C  (2023-10-28)
Created
May, B  (2023-05-12)
Cite Us!