Expression of PAX7 in the neural plate border

Stable Identifier
R-GGA-9835291
Type
Reaction [omitted]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of PAX7 in the neural plate border
PAX7 is expressed in lateral and posterior regions of the neural plate border after expression of MSX1, TFAP2A, and DLX5 have initiated (Khuyakov et al. 2009, Williams et al. 2022). Expression continues in the neural folds (Basch et al. 2006, Khudyakov et al. 2009). The TFAP2A:TFAP2C heterodimer (Rothstein and Simoes-Costa 2020) and MYB (Vadasz et al. 2013) bind the PAX7 gene and activate its expression in the neural plate border. FGF4 can also activate PAX7 expression in extra-embryonic ectodermal cells (Yardley and Garcia-Castro 2012).
Literature References
PubMed ID Title Journal Year
19235729 Comprehensive spatiotemporal analysis of early chick neural crest network genes

Khudyakov, J, Bronner-Fraser, M

Dev Dyn 2009
16688176 Specification of the neural crest occurs during gastrulation and requires Pax7

García-Castro, MI, Bronner-Fraser, M, Basch, ML

Nature 2006
35088714 Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

Bronner, ME, Lukoseviciute, M, Sauka-Spengler, T, Williams, RM

Elife 2022
23000357 FGF signaling transforms non-neural ectoderm into neural crest

Yardley, N, García-Castro, MI

Dev Biol 2012
23942518 Pax7 is regulated by cMyb during early neural crest development through a novel enhancer

Tulloch, M, Shylo, NA, García-Castro, MI, Vadasz, S, Marquez, J

Development 2013
31848212 Heterodimerization of TFAP2 pioneer factors drives epigenomic remodeling during neural crest specification

Simoes-Costa, M, Rothstein, M

Genome Res 2020
Participants
Input
Output
This event is regulated
Positively by
Regulator
MYB:PAX7 gene [nucleoplasm] (Gallus gallus)
Active Unit
MYB [nucleoplasm]
Regulator
FGF4 [extracellular region] (Gallus gallus)
Regulator
TFAP2A:TFAP2C:PAX7 gene [nucleoplasm] (Gallus gallus)
Active Unit
TFAP2A:TFAP2C [nucleoplasm]
Orthologous Events
Expression of PAX7 in the neural plate border (Homo sapiens)
Authored
May, B  (2023-05-12)
Reviewed
Patthey, C  (2023-10-28)
Gunhaga, L  (2023-10-28)
Created
May, B  (2023-05-12)
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