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p6 (P04591) protein [cytosol]
Stable Identifier
R-HIV-173425
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
cytosol
GO Cellular Component
host cell cytosol
(0044164)
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Annealing of 3'-end of unwound transfer RNA primer with genomic RNA (Homo sapiens)
RTC (Reverse Transcription Complex) with RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Binding and entry of HIV virion (Homo sapiens)
Fusion of viral membrane with host cell membrane (Homo sapiens)
Viral core surrounded by Matrix layer [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Formation of RTC (Reverse Transcription Complex) (Homo sapiens)
RTC (Reverse Transcription Complex) with RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
uncoated viral complex [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Integration of provirus (Homo sapiens)
Formation of Pre-Integration Complex (PIC) (Homo sapiens)
PIC (PreIntegration Complex) [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 [cytosol] (Homo sapiens)
RTC with integration competent viral DNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 (Homo sapiens)
RTC with integration competent viral DNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 [cytosol] (Homo sapiens)
RTC with integration competent viral DNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Import of PIC to the Host Nucleus (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Vpr:importin-alpha complex [cytosol] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Integrase binds viral DNA ends (Homo sapiens)
PIC (PreIntegration Complex) [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
viral DNA bound with Integrase in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Terminal (3' end) cleavage of viral DNA (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
viral DNA bound with Integrase in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA (Homo sapiens)
RTC with duplex DNA containing discontinuous plus strand flap [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with integration competent viral DNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Reverse Transcription of HIV RNA (Homo sapiens)
Minus-strand DNA synthesis (Homo sapiens)
First strand transfer mediated by Repeated (R) sequence (Homo sapiens)
RTC with degraded RNA template and minus sssDNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with minus sssDNA transferred to 3'-end of viral RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Minus strand DNA synthesis resumes (Homo sapiens)
RTC with minus sssDNA transferred to 3'-end of viral RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with minus strand DNA synthesis initiated from 3'-end [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)
RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with nicked minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RNase H-mediated cleavage of the template strand (Homo sapiens)
RTC with extensive RNase-H digestion [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with minus strand DNA synthesis initiated from 3'-end [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)
RTC with degraded RNA template and minus sssDNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with nicked minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RNase H-mediated degradation of the template strand (Homo sapiens)
RTC with extending minus strand DNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with extensive RNase-H digestion [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC binds NRTIs (Homo sapiens)
RTC with tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC:NRTIs [cytosol] (Homo sapiens)
RTC with tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Synthesis of minus strand strong stop DNA (-sssDNA) (Homo sapiens)
RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC:NRTIs [cytosol] (Homo sapiens)
RTC with tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Plus-strand DNA synthesis (Homo sapiens)
3' PPT-primed initiation of plus-strand DNA synthesis (Homo sapiens)
RTC with extending minus strand DNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with extending second-strand DNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers (Homo sapiens)
RTC with extending second-strand DNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC without viral RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Second strand transfer by annealing complementary PBS sequences (Homo sapiens)
RTC with annealed complementary PBS seqments in +sssDNA and -strand DNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC without viral RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Synthesis of full-length duplex viral DNA with a discontinuous plus strand (Homo sapiens)
RTC with annealed complementary PBS seqments in +sssDNA and -strand DNA [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with duplex DNA containing discontinuous plus strand flap [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Uncoating of the HIV Virion (Homo sapiens)
Disassembly of viral capsid (Homo sapiens)
Encapsidated viral core [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
uncoated viral complex [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Disintegration of matrix layer (Homo sapiens)
Encapsidated viral core [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Viral core surrounded by Matrix layer [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Host Interactions of HIV factors (Homo sapiens)
APOBEC3G mediated resistance to HIV-1 infection (Homo sapiens)
Association of APOBEC3G with Gag (Homo sapiens)
APOBEC3G:HIV-1PIC [cytosol] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand (Homo sapiens)
APOBEC3G:RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand (Homo sapiens)
APOBEC3G:RTC with deaminated minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
RTC with minus sssDNA containing deaminated C residues:tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
APOBEC3G:RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
RTC with minus sssDNA:tRNA primer:RNA template [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Interactions of Vpr with host cellular proteins (Homo sapiens)
Vpr-mediated nuclear import of PICs (Homo sapiens)
Interaction of Vpr with importin alpha (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Vpr:importin-alpha complex [cytosol] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
Vpr binds nucleoporins (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
PIC anchored to the NPC [nuclear envelope] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [cytosol] (Homo sapiens)
p6 protein [cytosol] (Human immunodeficiency virus 1)
p6 (P04591) protein [cytosol] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P04591 gag
Gene Names
gag
Chain
initiator methionine:, chain:2-500, chain:2-132, chain:133-363, peptide:364-377, chain:378-432, peptide:433-448, chain:449-500
Reference Genes
BioGPS Gene:155030 gag
KEGG:vg:155030 gag
Monarch:155030 gag
NCBI Gene:155030 gag
UCSC:P04591 gag
Reference Transcript
RefSeq:NC_001802.1 gag
Participates
as a member of
p6 protein [cytosol] (Human immunodeficiency virus 1)
Other forms of this molecule
MA (P04591) protein [cytosol]
GAG Polyprotein (P04591) [cytosol]
NC (P04591) protein [extracellular region]
MA (P04591) protein [extracellular region]
CA (P04591) protein [extracellular region]
p6 (P04591) protein [extracellular region]
CA (P04591) protein [cytosol]
NC (P04591) protein [cytosol]
p6 (P04591) [nucleoplasm]
MA (P04591) protein [nucleoplasm]
N-myristoyl GAG (P04591) protein [cytosol]
N-myristoyl GAG (P04591) protein [endosome membrane]
N-myristoyl GAG [plasma membrane]
N-myristoyl GAG (P04591) protein [extracellular region]
Cross References
PRO
P04591
PDB
6CQJ
,
6CQN
,
5IND
,
6CQQ
,
6ZDJ
,
5I1R
,
7ASH
,
6CQR
,
7ASL
,
6ECN
,
6ECO
,
5INC
,
1TSU
,
6CQL
,
5FJB
,
7WJ2
,
1TSQ
,
6EC2
,
6CPL
,
5NMF
,
5NMG
,
6CPO
,
6CPN
,
5NME
,
6N3U
,
5NMH
,
6N3J
,
5NMK
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HD40 SEPSECS
1
PXLP-K284-SEPSECS [cytosol]
(R-HSA-5357718)
0.558
3
UniProt:O95793-2 STAU1
0.471
4
UniProt:Q9Y6V7 DDX49
1
DDX49 [nucleoplasm]
(R-HSA-6790725)
0.462
2
UniProt:Q9NTK5 OLA1
2
OLA1 [extracellular region]
(R-HSA-8863004)
OLA1 [platelet alpha granule lumen]
(R-HSA-8862978)
0.462
2
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