Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
VPU (P05919) protein [extracellular region]
Stable Identifier
R-HIV-175522
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Binding and entry of HIV virion (Homo sapiens)
Binding of gp120 of ENV oligomer to the host CD4 (Homo sapiens)
Mature HIV virion [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Conformational change in gp120 of Env oligomer (Homo sapiens)
Virion with CD4 bound to gp120 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with exposed coreceptor binding sites [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Conformational changes in gp120 exposes gp41 (Homo sapiens)
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Fusion of viral membrane with host cell membrane (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Fusogenic activation of gp41 (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 exposed [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)
Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)
Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Late Phase of HIV Life Cycle (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Immature HIV virion [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Maturation of HIV Virion (Homo sapiens)
Immature HIV virion [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
Mature HIV virion [extracellular region] (Homo sapiens)
VPU (P05919) protein [extracellular region] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P05919 vpu
Gene Names
vpu
Chain
chain:1-81
Participant Of
hasComponent
Immature HIV virion [extracellular region]
Mature HIV virion [extracellular region]
Virion with CD4 bound to gp120 [extracellular region]
Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region]
Virion with exposed coreceptor binding sites [extracellular region]
Virion with fusogenically activated gp41 [extracellular region]
Virion with gp41 exposed [extracellular region]
Virion with gp41 forming hairpin structure [extracellular region]
Virion with gp41 fusion peptide in insertion complex [extracellular region]
Other forms of this molecule
VPU (P05919) protein [cytosol]
VPU (P05919) protein [nucleoplasm]
VPU (P05919) [endoplasmic reticulum membrane]
VPU (P05919) [Golgi membrane]
VPU (P05919) [plasma membrane]
Cross References
PDB
2N29
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.597
3
UniProt:Q13616 CUL1
3
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [cytosol]
(R-HSA-174230)
0.597
4
UniProt:P01730 CD4
4
CD4 [early endosome]
(R-HSA-182147)
CD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869082)
CD4 [endoplasmic reticulum membrane]
(R-HSA-180575)
CD4 [plasma membrane]
(R-HSA-167542)
0.524
3
UniProt:Q9NQC3 RTN4
1
RTN4 [plasma membrane]
(R-HSA-194556)
0.462
4
UniProt:Q9GZT3 SLIRP
0.462
4
UniProt:P42695 NCAPD3
3
p-T1415-NCAPD3 [nucleoplasm]
(R-HSA-2294587)
p-T1415,S1419-NCAPD3 [nucleoplasm]
(R-HSA-2294594)
NCAPD3 [nucleoplasm]
(R-HSA-1629790)
0.462
2
UniProt:Q99653 CHP1
1
p-CHP1 [plasma membrane]
(R-HSA-5333747)
0.462
2
UniProt:P13598 ICAM2
1
ICAM2 [plasma membrane]
(R-HSA-197852)
0.462
2
UniProt:O14980 XPO1
2
XPO1 [nucleoplasm]
(R-HSA-165529)
XPO1 [cytosol]
(R-HSA-165539)
0.462
2
UniProt:Q63HN8 RNF213
2
RNF213 [cytosol]
(R-HSA-8850897)
RNF213 [cytosol]
(R-HSA-9635613)
0.462
2
UniProt:P78527 PRKDC
4
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.462
2
UniProt:O95197 RTN3
1
RTN3 [plasma membrane]
(R-HSA-8849907)
0.462
4
UniProt:P06576 ATP5F1B
6
ATP5B(1-47) [mitochondrial matrix]
(R-HSA-8986172)
ATP5B [mitochondrial inner membrane]
(R-HSA-1299441)
ATP5B(1-529) [mitochondrial inner membrane]
(R-HSA-1299440)
ATP5B(1-529) [mitochondrial intermembrane space]
(R-HSA-1267985)
ATP5B(1-529) [cytosol]
(R-HSA-1267973)
ATP5B [mitochondrial matrix]
(R-HSA-164576)
0.462
2
UniProt:Q15185 PTGES3
2
PTGES3 [cytosol]
(R-HSA-265269)
PTGES3 [nucleoplasm]
(R-HSA-5082403)
0.462
2
UniProt:P26038 MSN
1
MSN [cytosol]
(R-HSA-437350)
0.462
2
UniProt:Q86T03 PIP4P1
2
TMEM55B [nucleoplasm]
(R-HSA-6810405)
TMEM55B [late endosome membrane]
(R-HSA-6810395)
0.462
4
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.462
4
UniProt:Q8TC07 TBC1D15
1
TBC1D15 [cytosol]
(R-HSA-8854150)
0.462
2
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.462
4
UniProt:O14828 SCAM3
0.462
4
UniProt:Q9UHQ9 CYB5R1
3
CYB5R1 [platelet alpha granule membrane]
(R-HSA-8848891)
CYB5R1 [plasma membrane]
(R-HSA-8848888)
CYB5R1 [endoplasmic reticulum membrane]
(R-HSA-6806847)
0.462
4
UniProt:P78357 CNTNAP1
1
CNTNAP1 [plasma membrane]
(R-HSA-373626)
0.462
2
UniProt:Q16537 PPP2R5E
1
PPP2R5E [cytosol]
(R-HSA-1638770)
0.462
2
UniProt:Q9NVI7 ATD3A
0.462
4
UniProt:P24539 ATP5PB
1
ATP5F1 [mitochondrial inner membrane]
(R-HSA-164537)
0.462
2
UniProt:Q9HAV4 XPO5
2
XPO5 [nucleoplasm]
(R-HSA-847721)
XPO5 [cytosol]
(R-HSA-847719)
0.462
2
UniProt:Q96P70 IPO9
0.462
4
UniProt:Q96F15 GIMA5
0.462
2
UniProt:P48047 ATP5PO
1
ATP5O [mitochondrial inner membrane]
(R-HSA-164533)
0.462
2
UniProt:Q86XR8 CEP57
1
CEP57 [cytosol]
(R-HSA-380271)
0.462
2
UniProt:P30049 ATP5F1D
1
ATP5D [mitochondrial matrix]
(R-HSA-164574)
0.462
2
UniProt:O95573 ACSL3
2
ACSL3 [mitochondrial outer membrane]
(R-HSA-9632656)
ACSL3 [endoplasmic reticulum membrane]
(R-HSA-548787)
0.462
2
UniProt:Q53GQ0 HSD17B12
1
HSD17B12 [endoplasmic reticulum membrane]
(R-HSA-548766)
0.462
2
UniProt:Q969Z0 FAKD4
0.462
2
UniProt:Q9Y6D6 BIG1
0.462
2
UniProt:Q9Y6D5 ARFGEF2
1
ARFGEF2 [cytosol]
(R-HSA-391301)
0.462
2
UniProt:P55084 HADHB
1
HADHB [mitochondrial inner membrane]
(R-HSA-77266)
0.462
4
UniProt:P18859 ATP5PF
1
ATP5J [mitochondrial inner membrane]
(R-HSA-164532)
0.462
4
UniProt:Q5T9A4 ATAD3B
3
ATAD3B [plasma membrane]
(R-HSA-6806518)
ATAD3B [secretory granule membrane]
(R-HSA-6801313)
ATAD3B [ficolin-1-rich granule membrane]
(R-HSA-6801277)
0.462
4
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.462
4
UniProt:Q9UBB4 ATX10
0.462
4
UniProt:P20020 ATP2B1
1
ATP2B1 [plasma membrane]
(R-HSA-418301)
0.462
2
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.462
4
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text