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VPU (P05919) [endoplasmic reticulum membrane]
Stable Identifier
R-HIV-180550
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
endoplasmic reticulum membrane
GO Cellular Component
host cell endoplasmic reticulum membrane
(0044167)
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Assembly Of The HIV Virion (Homo sapiens)
Synthesis and processing of ENV and VPU (Homo sapiens)
Synthesis of VPU protein (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
Transport of VPU to Golgi apparatus (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
Host Interactions of HIV factors (Homo sapiens)
Vpu mediated degradation of CD4 (Homo sapiens)
Association of Vpu with CD4 (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
Degradation of ubiquitinated CD4 (Homo sapiens)
Vpu:beta-TrCP1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
multiubiquitinated CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
The Vpu:CD4:beta-TrCP complex recruits SKP1 (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex (Homo sapiens)
CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
multiubiquitinated CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
Vpu:CD4 associates with beta-TrCP (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane] (Homo sapiens)
CD4:Vpu complex [endoplasmic reticulum membrane] (Homo sapiens)
VPU (P05919) [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P05919 vpu
Gene Names
vpu
Chain
chain:1-81
Participant Of
hasComponent
CD4:Vpu complex [endoplasmic reticulum membrane]
Vpu:beta-TrCP1:Skp1 complex [endoplasmic reticulum membrane]
input
Association of Vpu with CD4
Transport of VPU to Golgi apparatus
output
Synthesis of VPU protein
Other forms of this molecule
VPU (P05919) protein [extracellular region]
VPU (P05919) protein [cytosol]
VPU (P05919) protein [nucleoplasm]
VPU (P05919) [Golgi membrane]
VPU (P05919) [plasma membrane]
Cross References
PDB
2N29
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.597
3
UniProt:Q13616 CUL1
3
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [cytosol]
(R-HSA-174230)
0.597
4
UniProt:P01730 CD4
4
CD4 [early endosome]
(R-HSA-182147)
CD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869082)
CD4 [endoplasmic reticulum membrane]
(R-HSA-180575)
CD4 [plasma membrane]
(R-HSA-167542)
0.524
3
UniProt:Q9NQC3 RTN4
1
RTN4 [plasma membrane]
(R-HSA-194556)
0.462
4
UniProt:Q9GZT3 SLIRP
0.462
4
UniProt:P42695 NCAPD3
3
p-T1415-NCAPD3 [nucleoplasm]
(R-HSA-2294587)
p-T1415,S1419-NCAPD3 [nucleoplasm]
(R-HSA-2294594)
NCAPD3 [nucleoplasm]
(R-HSA-1629790)
0.462
2
UniProt:Q99653 CHP1
1
p-CHP1 [plasma membrane]
(R-HSA-5333747)
0.462
2
UniProt:P13598 ICAM2
1
ICAM2 [plasma membrane]
(R-HSA-197852)
0.462
2
UniProt:O14980 XPO1
2
XPO1 [nucleoplasm]
(R-HSA-165529)
XPO1 [cytosol]
(R-HSA-165539)
0.462
2
UniProt:Q63HN8 RNF213
2
RNF213 [cytosol]
(R-HSA-8850897)
RNF213 [cytosol]
(R-HSA-9635613)
0.462
2
UniProt:P78527 PRKDC
4
PRKDC [nucleoplasm]
(R-HSA-62161)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [cytosol]
(R-HSA-3134816)
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
0.462
2
UniProt:O95197 RTN3
1
RTN3 [plasma membrane]
(R-HSA-8849907)
0.462
4
UniProt:P06576 ATP5F1B
6
ATP5B(1-47) [mitochondrial matrix]
(R-HSA-8986172)
ATP5B [mitochondrial inner membrane]
(R-HSA-1299441)
ATP5B(1-529) [mitochondrial inner membrane]
(R-HSA-1299440)
ATP5B(1-529) [mitochondrial intermembrane space]
(R-HSA-1267985)
ATP5B(1-529) [cytosol]
(R-HSA-1267973)
ATP5B [mitochondrial matrix]
(R-HSA-164576)
0.462
2
UniProt:Q15185 PTGES3
2
PTGES3 [cytosol]
(R-HSA-265269)
PTGES3 [nucleoplasm]
(R-HSA-5082403)
0.462
2
UniProt:P26038 MSN
1
MSN [cytosol]
(R-HSA-437350)
0.462
2
UniProt:Q86T03 PIP4P1
2
TMEM55B [nucleoplasm]
(R-HSA-6810405)
TMEM55B [late endosome membrane]
(R-HSA-6810395)
0.462
4
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.462
4
UniProt:Q8TC07 TBC1D15
1
TBC1D15 [cytosol]
(R-HSA-8854150)
0.462
2
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.462
4
UniProt:O14828 SCAM3
0.462
4
UniProt:Q9UHQ9 CYB5R1
3
CYB5R1 [platelet alpha granule membrane]
(R-HSA-8848891)
CYB5R1 [plasma membrane]
(R-HSA-8848888)
CYB5R1 [endoplasmic reticulum membrane]
(R-HSA-6806847)
0.462
4
UniProt:P78357 CNTNAP1
1
CNTNAP1 [plasma membrane]
(R-HSA-373626)
0.462
2
UniProt:Q16537 PPP2R5E
1
PPP2R5E [cytosol]
(R-HSA-1638770)
0.462
2
UniProt:Q9NVI7 ATD3A
0.462
4
UniProt:P24539 ATP5PB
1
ATP5F1 [mitochondrial inner membrane]
(R-HSA-164537)
0.462
2
UniProt:Q9HAV4 XPO5
2
XPO5 [nucleoplasm]
(R-HSA-847721)
XPO5 [cytosol]
(R-HSA-847719)
0.462
2
UniProt:Q96P70 IPO9
0.462
4
UniProt:Q96F15 GIMA5
0.462
2
UniProt:P48047 ATP5PO
1
ATP5O [mitochondrial inner membrane]
(R-HSA-164533)
0.462
2
UniProt:Q86XR8 CEP57
1
CEP57 [cytosol]
(R-HSA-380271)
0.462
2
UniProt:P30049 ATP5F1D
1
ATP5D [mitochondrial matrix]
(R-HSA-164574)
0.462
2
UniProt:O95573 ACSL3
2
ACSL3 [mitochondrial outer membrane]
(R-HSA-9632656)
ACSL3 [endoplasmic reticulum membrane]
(R-HSA-548787)
0.462
2
UniProt:Q53GQ0 HSD17B12
1
HSD17B12 [endoplasmic reticulum membrane]
(R-HSA-548766)
0.462
2
UniProt:Q969Z0 FAKD4
0.462
2
UniProt:Q9Y6D6 BIG1
0.462
2
UniProt:Q9Y6D5 ARFGEF2
1
ARFGEF2 [cytosol]
(R-HSA-391301)
0.462
2
UniProt:P55084 HADHB
1
HADHB [mitochondrial inner membrane]
(R-HSA-77266)
0.462
4
UniProt:P18859 ATP5PF
1
ATP5J [mitochondrial inner membrane]
(R-HSA-164532)
0.462
4
UniProt:Q5T9A4 ATAD3B
3
ATAD3B [plasma membrane]
(R-HSA-6806518)
ATAD3B [secretory granule membrane]
(R-HSA-6801313)
ATAD3B [ficolin-1-rich granule membrane]
(R-HSA-6801277)
0.462
4
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.462
4
UniProt:Q9UBB4 ATX10
0.462
4
UniProt:P20020 ATP2B1
1
ATP2B1 [plasma membrane]
(R-HSA-418301)
0.462
2
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.462
4
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