Reactome | Envelope glycoprotein gp160 [endoplasmic reticulum membrane]

Envelope glycoprotein gp160 [endoplasmic reticulum membrane]

Stable Identifier

R-HIV-189343

Type

Protein [EntityWithAccessionedSequence]

Species

Human immunodeficiency virus 1

Compartment

endoplasmic reticulum membrane

GO Cellular Component

host cell endoplasmic reticulum membrane (0044167)

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04578 env

Gene Names

env

Chain

signal peptide:1-32, chain:33-856, chain:33-511, chain:512-856

Reference Genes

BioGPS Gene:155971 env

KEGG Gene (Addendum):NP_057856-1 env

KEGG Gene (Hepatitis C Virus):155971 env

Monarch:155971 env

NCBI Gene:155971 env

Reference Transcript

RefSeq:NC_001802.1 env

Participates

as an output of

as an input of

as a component of

Trimeric ENV precursor [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)

Other forms of this molecule

Surface protein gp120 (P04578) [cytosol]

Transmembrane protein gp41 (P04578) [cytosol]

Glycosylated Envelope glycoprotein gp160 [Golgi membrane]

Transmembrane protein gp41 [viral envelope]

Surface protein gp120 [viral envelope]

ENV [viral envelope]

Cross References

RefSeq

NP_057856.1

ZINC - Substances

ENV_HV1H2

ZINC target

P04578

PRO

P04578

ZINC - Predictions - Purchasable

ENV_HV1H2

PDB

6NPR, 3D0V, 5ZCX, 1AIK, 5X08, 5H0N, 2NY7, 4ZTO, 5YC0, 1G9M, 6SNC, 6P8D, 3DNO, 1K33, 6PDR, 6SNE, 3DNN, 5HFL, 1DF5, 6NCP, 3TYG, 6DE7, 5YB3, 3MNZ, 1MZI, 6MQC, 6P60, 5NWU, 5CMZ, 1OPT, 6BXP, 6MQM, 6UCF, 5TKJ, 1FAV, 5CIL, 6MQS, 5GHW, 5C0R, 5IVX, 5BN0, 6PDS, 3DNL, 2PV6, 1OPN, 4JPJ, 1DF4, 6UBI, 6PEC, 3IDY, 6O3G, 5KA6, 6UJV, 3IDX, 4YDV, 6O3L, 2MG3, 6JQK, 6B9K, 2XRA, 2MG2, 2ME1, 1RZJ, 6J5E, 3DRO, 6SND, 6DLN, 6PSA, 5YB2, 5YB4, 6P7H, 2CMR, 1OPW, 5DD0, 6MQE, 6O42, 1GZL, 6UCE, 5NWW, 2MG1, 5CMU, 6BXQ, 5CN0, 1K34, 1DLB, 5CIN, 6MQR, 5TKK, 3VIE, 5C0S, 6N16, 5HM1, 5NVP, 4JPK, 6PDU, 6KTS, 6RYF, 1GC1, 3J70, 5Z0W, 5KA5, 6UJU, 6O3J, 6PEF, 5WDF

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.623	3
UniProt:Q9ULD8 KCNH3	1	KCNH3 [plasma membrane] (R-HSA-977527)	0.591	3
UniProt:P01730 CD4	4	CD4 [early endosome] (R-HSA-182147) CD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869082) CD4 [endoplasmic reticulum membrane] (R-HSA-180575) CD4 [plasma membrane] (R-HSA-167542)	0.558	2
UniProt:Q15165 PON2	1	PON2 [extracellular region] (R-HSA-8932636)	0.462	2
UniProt:Q9NWW5 CLN6			0.462	2
UniProt:P28072 PSMB6	2	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342)	0.462	2
UniProt:P45880 VDAC2	2	PolyUb-VDAC2 [mitochondrial outer membrane] (R-HSA-6783185) VDAC2 [mitochondrial outer membrane] (R-HSA-5696880)	0.462	2
UniProt:Q07065 CKAP4	7	PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285) CKAP4 [azurophil granule membrane] (R-HSA-6799559) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [specific granule membrane] (R-HSA-6799552) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737)	0.462	4
UniProt:P61619 SEC61A1	2	SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813) SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591)	0.462	2
UniProt:P05107 ITGB2	4	ITGB2 [tertiary granule membrane] (R-HSA-6803342) ITGB2 [specific granule membrane] (R-HSA-6803284) ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310) ITGB2 [plasma membrane] (R-HSA-198010)	0.462	2
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.462	3
UniProt:P20701 ITGAL	2	ITGAL [plasma membrane] (R-HSA-198013) ITGAL [specific granule membrane] (R-HSA-6799536)	0.462	2
UniProt:Q6DD88 ATLA3			0.462	2
UniProt:Q9HCN8 SDF2L			0.462	4
UniProt:Q9BYC5 FUT8	1	FUT8 [Golgi membrane] (R-HSA-1028782)	0.462	2
UniProt:P49257 LMAN1	4	LMAN1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689821) LMAN1 [Golgi membrane] (R-HSA-9715113) LMAN1 [endoplasmic reticulum membrane] (R-HSA-5689463) LMAN1 [ER to Golgi transport vesicle membrane] (R-HSA-1017222)	0.462	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.462	2
UniProt:P43630 KIR3DL2	1	KIR3DL2 [plasma membrane] (R-HSA-197713)	0.462	2
UniProt:O14967 CLGN			0.462	2
UniProt:P51571 SSR4	1	SSR4 [endoplasmic reticulum membrane] (R-HSA-265026)	0.462	2
UniProt:P07339 CTSD	10	CTSD(169-412) [lysosomal lumen] (R-HSA-9023737) CTSD(65-161) [lysosomal lumen] (R-HSA-9023739) CTSD(65-412) [lysosomal lumen] (R-HSA-1181223) CTSD(65-161) [extracellular region] (R-HSA-2228718) CTSD(169-412) [extracellular region] (R-HSA-2471614) CTSD(65-412) [tertiary granule lumen] (R-HSA-6801276) CTSD(65-412) [specific granule lumen] (R-HSA-6801272) CTSD(65-412) [ficolin-1-rich granule lumen] (R-HSA-6801321) CTSD(65-412) [plasma membrane] (R-HSA-2990852) CTSD(65-412) [extracellular region] (R-HSA-2990853)	0.462	2
UniProt:Q96DZ1 ERLEC1	1	ERLEC1 [endoplasmic reticulum quality control compartment] (R-HSA-5362354)	0.462	3
UniProt:Q9H3P7 ACBD3	1	ACBD3 [Golgi membrane] (R-HSA-8874981)	0.462	2
UniProt:Q9NYU2 UGGT1	1	UGGT1 [endoplasmic reticulum lumen] (R-HSA-548864)	0.462	2
UniProt:Q8TCT9 HM13	1	HM13 [endoplasmic reticulum membrane] (R-HSA-9708544)	0.462	2
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.462	2
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.462	4
UniProt:Q13112 CAF1B			0.462	2
UniProt:P14314 PRKCSH	3	p-PRKCSH [endoplasmic reticulum lumen] (R-HSA-8956890) PRKCSH [plasma membrane] (R-HSA-879405) PRKCSH [endoplasmic reticulum lumen] (R-HSA-532666)	0.462	4
UniProt:Q9Y282 ERGI3			0.462	2
UniProt:O00264 PGRMC1	2	PGRMC1 [specific granule membrane] (R-HSA-6799648) PGRMC1 [plasma membrane] (R-HSA-6806314)	0.462	2
UniProt:Q96EE3 SEH1L	1	SEH1L [lysosomal membrane] (R-HSA-9638217)	0.462	2
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.462	2
UniProt:P16615 ATP2A2	2	ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903) ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)	0.462	2
UniProt:Q99470 SDF2			0.462	4
UniProt:O94901 SUN1	1	SUN1 [nuclear envelope] (R-HSA-912371)	0.462	3
UniProt:Q9BXS5 AP1M1	7	AP1M1 [Golgi membrane] (R-HSA-350805) AP1M1 [cytoplasmic vesicle membrane] (R-HSA-351196) AP1M1 [lysosomal membrane] (R-HSA-432708) AP1M1 [trans-Golgi network membrane] (R-HSA-2130512) AP1M1 [cytosol] (R-HSA-167700) AP1M1 [plasma membrane] (R-HSA-6806311) AP1M1 [specific granule membrane] (R-HSA-6799365)	0.462	2
UniProt:P01850 TRBC1	1	TRBC1 [plasma membrane] (R-HSA-198188)	0.462	2
UniProt:Q96IV0 NGLY1	1	NGLY1 [cytosol] (R-HSA-8850591)	0.462	2
UniProt:P13073 COX4I1	1	COX4I1 [mitochondrial inner membrane] (R-HSA-164305)	0.462	2
UniProt:Q14697 GANAB	1	GANAB [endoplasmic reticulum lumen] (R-HSA-532674)	0.462	4
UniProt:Q14696 MESD			0.462	2
UniProt:P07237 P4HB	3	p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) P4HB [endoplasmic reticulum lumen] (R-HSA-174692) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.462	2
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.462	2
UniProt:P01733 TRBV12-3	1	TRBV12-3 [plasma membrane] (R-HSA-198181)	0.462	2
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.462	4
UniProt:Q15392 DHCR24	1	DHCR24 [endoplasmic reticulum membrane] (R-HSA-196414)	0.462	2
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.462	2
UniProt:Q9UBV2 SEL1L	1	SEL1L [endoplasmic reticulum membrane] (R-HSA-1911545)	0.462	4
UniProt:P01130 LDLR	4	LDLR [endosome membrane] (R-HSA-171127) LDLR [endolysosome membrane] (R-HSA-6784818) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [plasma membrane] (R-HSA-171053)	0.462	2