Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
Stable Identifier
R-HIV-189343
Type
Protein [EntityWithAccessionedSequence]
Species
Human immunodeficiency virus 1
Compartment
endoplasmic reticulum membrane
GO Cellular Component
host cell endoplasmic reticulum membrane
(0044167)
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9Y287 ITM2B
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Assembly Of The HIV Virion (Homo sapiens)
Synthesis and processing of ENV and VPU (Homo sapiens)
Folding and Oligomerization of ENV glycoprotein (Homo sapiens)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
Glycosylation of ENV polyprotein (Homo sapiens)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
Synthesis of ENV polyprotein (Homo sapiens)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
External Reference Information
External Reference
UniProt:P04578 env
Gene Names
env
Chain
signal peptide:1-32, chain:33-856, chain:33-511, chain:512-856
Reference Genes
BioGPS Gene:155971 env
KEGG:vg:155971 env
Monarch:155971 env
NCBI Gene:155971 env
UCSC:P04578 env
Reference Transcript
RefSeq:NC_001802.1 env
Participates
as an output of
Synthesis of ENV polyprotein (Homo sapiens)
Glycosylation of ENV polyprotein (Homo sapiens)
as an input of
Glycosylation of ENV polyprotein (Homo sapiens)
Folding and Oligomerization of ENV glycoprotein (Homo sapiens)
as a component of
Trimeric ENV precursor [endoplasmic reticulum membrane] (Human immunodeficiency virus 1)
Other forms of this molecule
ENV [viral envelope]
Surface protein gp120 [viral envelope]
Transmembrane protein gp41 [viral envelope]
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
Transmembrane protein gp41 (P04578) [cytosol]
Surface protein gp120 (P04578) [cytosol]
Cross References
RefSeq
NP_057856.1
ZINC - Substances
ENV_HV1H2
ZINC target
P04578
PRO
P04578
ZINC - Predictions - Purchasable
ENV_HV1H2
PDB
6UJV
,
7EKK
,
8F3B
,
5YB2
,
7R73
,
6JQK
,
6O3G
,
6BXP
,
1K33
,
5ZCX
,
1GZL
,
3VIE
,
1AIK
,
5CIL
,
5IVX
,
4ZTO
,
8B6Y
,
6MQE
,
3D0V
,
2CMR
,
6MQR
,
5NVP
,
8TQ8
,
3TYG
,
6SNC
,
6PDS
,
7LOI
,
3J70
,
5YC0
,
1GC1
,
6UJU
,
5CN0
,
3MNZ
,
7RDW
,
4YDV
,
2XRA
,
5BN0
,
6N16
,
6O42
,
2MG3
,
8FZ2
,
5GHW
,
5C0R
,
6PSA
,
1MZI
,
7FF1
,
2NY7
,
6UCE
,
5TKK
,
6MQM
,
1FAV
,
5KA6
,
1DF5
,
6RYF
,
4JPK
,
7R74
,
7N08
,
3IDX
,
6DLN
,
6P8D
,
5YB4
,
7EKB
,
7AEJ
,
6BXQ
,
6KTS
,
8F3A
,
3DNO
,
6PDU
,
1G9M
,
2MG2
,
6NCP
,
2PV6
,
5NWW
,
5CMZ
,
6WWC
,
1RZJ
,
5TKJ
,
8TQ9
,
5CIN
,
6SNE
,
1DF4
,
5Z0W
,
6P7H
,
2ME1
,
6PDR
,
6O3J
,
6DE7
,
3DNN
,
3IDY
,
6UCF
,
4JPJ
,
6UBI
,
6B9K
,
5YB3
,
6P60
,
5WDF
,
1K34
,
3DNL
,
1DLB
,
6PEF
,
2MG1
,
5C0S
,
5CMU
,
6NPR
,
5HM1
,
3DRO
,
8FYM
,
5NWU
,
6MQS
,
5HFL
,
8TQ7
,
5DD0
,
5KA5
,
6MQC
,
6SND
,
6O3L
,
6PEC
,
7LOH
,
5X08
,
6J5E
,
7N05
,
5H0N
Interactors (50)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.623
3
UniProt:Q9ULD8 KCNH3
1
KCNH3 [plasma membrane]
(R-HSA-977527)
0.591
3
UniProt:P01730 CD4
4
CD4 [plasma membrane]
(R-HSA-167542)
CD4 [endoplasmic reticulum membrane]
(R-HSA-180575)
CD4 [early endosome]
(R-HSA-182147)
CD4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869082)
0.558
2
UniProt:Q15165 PON2
1
PON2 [extracellular region]
(R-HSA-8932636)
0.462
2
UniProt:Q9NWW5 CLN6
0.462
2
UniProt:P45880 VDAC2
6
p-S65-Ub:VDAC2 [mitochondrial outer membrane]
(R-HSA-9834982)
K63polyUb-VDAC2 [mitochondrial outer membrane]
(R-HSA-9843314)
K48polyUb-VDAC2 [mitochondrial outer membrane]
(R-HSA-9843321)
Ub-VDAC2 [mitochondrial outer membrane]
(R-HSA-9835025)
VDAC2 [mitochondrial outer membrane]
(R-HSA-5696880)
PolyUb-VDAC2 [mitochondrial outer membrane]
(R-HSA-6783185)
0.462
2
UniProt:P61619 SEC61A1
2
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
0.462
2
UniProt:P05107 ITGB2
4
ITGB2 [plasma membrane]
(R-HSA-198010)
ITGB2 [ficolin-1-rich granule membrane]
(R-HSA-6803310)
ITGB2 [specific granule membrane]
(R-HSA-6803284)
ITGB2 [tertiary granule membrane]
(R-HSA-6803342)
0.462
2
UniProt:Q9Y287 ITM2B
1
ITM2B(244-266) [extracellular region]
(R-HSA-976878)
0.462
3
UniProt:P20701 ITGAL
2
ITGAL [plasma membrane]
(R-HSA-198013)
ITGAL [specific granule membrane]
(R-HSA-6799536)
0.462
2
UniProt:Q6DD88 ATLA3
0.462
2
UniProt:Q9HCN8 SDF2L
0.462
4
UniProt:P49257 LMAN1
4
LMAN1 [Golgi membrane]
(R-HSA-9715113)
LMAN1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689821)
LMAN1 [ER to Golgi transport vesicle membrane]
(R-HSA-1017222)
LMAN1 [endoplasmic reticulum membrane]
(R-HSA-5689463)
0.462
3
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.462
2
UniProt:P43630 KIR3DL2
1
KIR3DL2 [plasma membrane]
(R-HSA-197713)
0.462
2
UniProt:Q15392 DHCR24
1
DHCR24 [endoplasmic reticulum membrane]
(R-HSA-196414)
0.462
2
UniProt:Q07065 CKAP4
7
CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956737)
p-CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956926)
CKAP4 [azurophil granule membrane]
(R-HSA-6799559)
CKAP4 [plasma membrane]
(R-HSA-5686306)
CKAP4 [specific granule membrane]
(R-HSA-6799552)
PALM-C100-CKAP4 [plasma membrane]
(R-HSA-5686280)
PALM-C100-CKAP4 [lamellar body]
(R-HSA-5686285)
0.462
4
UniProt:Q9UBS4 DNAJB11
1
DNAJB11 [endoplasmic reticulum lumen]
(R-HSA-381040)
0.462
4
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.462
2
UniProt:P30101 PDIA3
3
PDIA3 [phagocytic vesicle]
(R-HSA-1236870)
PDIA3 [recycling endosome membrane]
(R-HSA-8863849)
PDIA3 [endoplasmic reticulum lumen]
(R-HSA-901028)
0.462
2
UniProt:P01130 LDLR
4
LDLR [plasma membrane]
(R-HSA-171053)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [endolysosome membrane]
(R-HSA-6784818)
0.462
2
UniProt:Q9H3P7 ACBD3
1
ACBD3 [Golgi membrane]
(R-HSA-8874981)
0.462
2
UniProt:Q9UBV2 SEL1L
1
SEL1L [endoplasmic reticulum membrane]
(R-HSA-1911545)
0.462
4
UniProt:Q9BYC5 FUT8
1
FUT8 [Golgi membrane]
(R-HSA-1028782)
0.462
2
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.462
4
UniProt:P28072 PSMB6
4
PSMB6 [cytosol]
(R-HSA-68756)
PSMB6 [nucleoplasm]
(R-HSA-174342)
pro-PSMB6 [cytosol]
(R-HSA-9908130)
PSMB6(1-34) [cytosol]
(R-HSA-9908141)
0.462
2
UniProt:P01733 TRBV12-3
1
TRBV12-3 [plasma membrane]
(R-HSA-198181)
0.462
2
UniProt:P04843 RPN1
1
RPN1 [endoplasmic reticulum membrane]
(R-HSA-264994)
0.462
2
UniProt:Q14696 MESD
0.462
2
UniProt:P13073 COX4I1
2
COX4I1 [mitochondrial intermembrane space]
(R-HSA-9865413)
COX4I1 [mitochondrial inner membrane]
(R-HSA-164305)
0.462
2
UniProt:Q14697 GANAB
1
GANAB [endoplasmic reticulum lumen]
(R-HSA-532674)
0.462
4
UniProt:Q96IV0 NGLY1
1
NGLY1 [cytosol]
(R-HSA-8850591)
0.462
2
UniProt:P01850 TRBC1
1
TRBC1 [plasma membrane]
(R-HSA-198188)
0.462
2
UniProt:Q9BXS5 AP1M1
7
AP1M1 [cytoplasmic vesicle membrane]
(R-HSA-351196)
AP1M1 [Golgi membrane]
(R-HSA-350805)
AP1M1 [lysosomal membrane]
(R-HSA-432708)
AP1M1 [trans-Golgi network membrane]
(R-HSA-2130512)
AP1M1 [cytosol]
(R-HSA-167700)
AP1M1 [plasma membrane]
(R-HSA-6806311)
AP1M1 [specific granule membrane]
(R-HSA-6799365)
0.462
2
UniProt:Q99470 SDF2
0.462
4
UniProt:O94901 SUN1
1
SUN1 [nuclear envelope]
(R-HSA-912371)
0.462
3
UniProt:P16615 ATP2A2
2
ATP2A2 [platelet dense tubular network membrane]
(R-HSA-427903)
ATP2A2 [endoplasmic reticulum membrane]
(R-HSA-391962)
0.462
2
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.462
2
UniProt:O00264 PGRMC1
2
PGRMC1 [plasma membrane]
(R-HSA-6806314)
PGRMC1 [specific granule membrane]
(R-HSA-6799648)
0.462
2
UniProt:Q96EE3 SEH1L
1
SEH1L [lysosomal membrane]
(R-HSA-9638217)
0.462
2
UniProt:Q9Y282 ERGI3
0.462
2
UniProt:P14314 PRKCSH
3
PRKCSH [plasma membrane]
(R-HSA-879405)
p-PRKCSH [endoplasmic reticulum lumen]
(R-HSA-8956890)
PRKCSH [endoplasmic reticulum lumen]
(R-HSA-532666)
0.462
4
UniProt:Q13112 CAF1B
0.462
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.462
2
UniProt:Q8TCT9 HM13
1
HM13 [endoplasmic reticulum membrane]
(R-HSA-9708544)
0.462
2
UniProt:Q9NYU2 UGGT1
1
UGGT1 [endoplasmic reticulum lumen]
(R-HSA-548864)
0.462
2
UniProt:Q96DZ1 ERLEC1
1
ERLEC1 [endoplasmic reticulum quality control compartment]
(R-HSA-5362354)
0.462
3
UniProt:P07339 CTSD
12
CTSD(65-412) [extracellular region]
(R-HSA-2990853)
CTSD(65-412) [plasma membrane]
(R-HSA-2990852)
CTSD(169-412) [endosome lumen]
(R-HSA-9816128)
CTSD(65-161) [endosome lumen]
(R-HSA-9816123)
CTSD(65-412) [specific granule lumen]
(R-HSA-6801272)
CTSD(65-412) [tertiary granule lumen]
(R-HSA-6801276)
CTSD(65-412) [ficolin-1-rich granule lumen]
(R-HSA-6801321)
CTSD(169-412) [extracellular region]
(R-HSA-2471614)
CTSD(65-161) [extracellular region]
(R-HSA-2228718)
CTSD(65-412) [lysosomal lumen]
(R-HSA-1181223)
CTSD(169-412) [lysosomal lumen]
(R-HSA-9023737)
CTSD(65-161) [lysosomal lumen]
(R-HSA-9023739)
0.462
2
UniProt:P51571 SSR4
1
SSR4 [endoplasmic reticulum membrane]
(R-HSA-265026)
0.462
2
UniProt:O14967 CLGN
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text