Reactome | AK3 [mitochondrial matrix]

AK3 [mitochondrial matrix]

Stable Identifier

R-HSA-1008241

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Adenylate kinase 3, GTP:AMP phosphotransferase, mitochondrial, KAD3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UIJ7 AK3

Gene Names

AK3, AK3L1, AK6, AKL3L

Chain

chain:1-227

Reference Genes

BioGPS Gene:50808 AK3

COSMIC (genes):AK3 AK3

CTD Gene:50808 AK3

dbSNP Gene:50808 AK3

ENSEMBL:ENSG00000147853 AK3

ENSEMBL_homo_sapiens_GENE:ENSG00000147853.17 AK3

HGNC:17376 AK3

KEGG Gene (Homo sapiens):50808 AK3

Monarch:50808 AK3

NCBI Gene:50808 AK3

OMIM:609290 AK3

UCSC:Q9UIJ7 AK3

Reference Transcript

Other Identifiers

11723438_s_at

11748857_a_at

11757768_s_at

11758884_at

17092153

224151_PM_s_at

224151_s_at

224655_PM_at

224655_at

3157297

3197323

3197324

3197325

3197326

3197327

3197328

3197329

3197330

3197331

3197332

3197333

3197340

3197341

3197342

3197343

3197356

3197358

3197360

45084_at

49054_at

50808

8159945

A_24_P247106

A_24_P461998

A_33_P3263061

GE82099

GE876316

GO:0000166

GO:0003824

GO:0004017

GO:0005515

GO:0005524

GO:0005525

GO:0005737

GO:0005739

GO:0005759

GO:0006139

GO:0006172

GO:0007596

GO:0009117

GO:0009123

GO:0009142

GO:0016301

GO:0016310

GO:0016740

GO:0016776

GO:0019205

GO:0042060

GO:0043226

GO:0043231

GO:0046033

GO:0046039

GO:0046041

GO:0046051

GO:0046899

GO:0055086

GO:1901135

HMNXSV003050610

Hs.43436.1.S3_3p_at

Hs.43436.1.S3_3p_x_at

ILMN_1778173

ILMN_1871762

PH_hs_0003160

PH_hs_0031191

TC09000884.hg

g9963776_3p_a_at

Inferred To

Homologues of AK3 [mitochondrial matrix] (Canis familiaris)

AK3 [mitochondrial matrix] (Bos taurus)

AK3 [mitochondrial matrix] (Canis familiaris)

AK3 [mitochondrial matrix] (Dictyostelium discoideum)

AK3 [mitochondrial matrix] (Drosophila melanogaster)

AK3 [mitochondrial matrix] (Gallus gallus)

AK3 [mitochondrial matrix] (Mus musculus)

AK3 [mitochondrial matrix] (Plasmodium falciparum)

AK3 [mitochondrial matrix] (Rattus norvegicus)

AK3 [mitochondrial matrix] (Saccharomyces cerevisiae)

AK3 [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_057366.2, NP_001186782.1, NP_001186781.1, NP_001186785.1, NP_001186784.1

OpenTargets

ENSG00000147853

IntEnz

2.7.4.10

GeneCards

Q9UIJ7

HPA

ENSG00000147853-AK3

Ensembl

ENSP00000352948, ENSP00000482308, ENST00000359883, ENST00000447596, ENSG00000147853, ENSP00000371230, ENST00000611749, ENST00000381809, ENSP00000413933

PRO

Q9UIJ7

Pharos - Targets

Q9UIJ7

HMDB Protein

HMDBP00573

PDB

6ZJE, 6ZJD, 1ZD8, 6ZJB

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92624 APBP2			0.718	6
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P23560-2 BDNF			0.556	3
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [extracellular region] (R-HSA-174646) APOE-4 [extracellular region] (R-HSA-9711070) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:P23142-4 FBLN1			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q83B01 Q83B01			0.488	2

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