Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
DOCK8 [cytosol]
Stable Identifier
R-HSA-1011619
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dedicator of cytokinesis protein 8, DOCK8_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
DOCKs bind to RhoGEFs (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK8 [cytosol] (Homo sapiens)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK8 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
DOCK8 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK8 [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ GEFs activate RHOJ (Homo sapiens)
RHOJ GEFs [cytosol] (Homo sapiens)
DOCK8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NF50 DOCK8
Gene Names
DOCK8
Chain
chain:1-2099
Reference Genes
BioGPS Gene:81704 DOCK8
COSMIC (genes):DOCK8 DOCK8
CTD Gene:81704 DOCK8
dbSNP Gene:81704 DOCK8
ENSEMBL:ENSG00000107099 DOCK8
HGNC:19191 DOCK8
KEGG:hsa:81704 DOCK8
Monarch:81704 DOCK8
NCBI Gene:81704 DOCK8
OMIM:611432 DOCK8
UCSC:Q8NF50 DOCK8
Reference Transcript
RefSeq:XM_011518047.2 DOCK8
RefSeq:XM_047423929.1 DOCK8
RefSeq:XM_047423933.1 DOCK8
RefSeq:XM_011518048.2 DOCK8
RefSeq:NM_203447.4 DOCK8
RefSeq:NM_001193536.2 DOCK8
RefSeq:XM_017015173.2 DOCK8
RefSeq:XM_011518045.4 DOCK8
RefSeq:NM_001190458.2 DOCK8
Participates
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
as a member of
RHOJ GEFs [cytosol] (Homo sapiens)
Inferred To
dock8 [cytosol]
(Danio rerio)
dock8 [cytosol]
(Xenopus tropicalis)
zizD [cytosol]
(Dictyostelium discoideum)
zizA [cytosol]
(Dictyostelium discoideum)
zizB [cytosol]
(Dictyostelium discoideum)
DOCK8 [cytosol]
(Bos taurus)
DOCK8 [cytosol]
(Caenorhabditis elegans)
DOCK8 [cytosol]
(Canis familiaris)
DOCK8 [cytosol]
(Gallus gallus)
DOCK8 [cytosol]
(Sus scrofa)
Zir [cytosol]
(Drosophila melanogaster)
Homologues of DOCK8 [cytosol]
(Dictyostelium discoideum)
zizC [cytosol]
(Dictyostelium discoideum)
Dock8 [cytosol]
(Mus musculus)
Dock8 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_047279885.1
,
XP_011516349.1
,
XP_011516350.1
,
NP_001180465.1
,
XP_011516347.1
,
NP_001177387.1
,
NP_982272.2
,
XP_016870662.1
,
XP_047279889.1
ENSEMBL
ENST00000432829
,
ENST00000469391
,
ENSP00000394888
,
ENSP00000419438
,
ENST00000453981
,
ENSG00000107099
,
ENSP00000408464
OpenTargets
ENSG00000107099
GeneCards
DOCK8
HPA
ENSG00000107099-DOCK8
PRO
Q8NF50
Pharos - Targets
Q8NF50
GlyGen
Q8NF50
Orphanet
DOCK8
HMDB Protein
HMDBP08359
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99836 MYD88
8
MYD88 [cytosol]
(R-HSA-166059)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [endosome membrane]
(R-HSA-975123)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 R196C [cytosol]
(R-HSA-5602329)
0.576
3
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text