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DOCK8 [cytosol]
Stable Identifier
R-HSA-1011619
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dedicator of cytokinesis protein 8, DOCK8_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
DOCKs bind to RhoGEFs (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK8 [cytosol] (Homo sapiens)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK8 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
DOCK8 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK8 [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ GEFs activate RHOJ (Homo sapiens)
RHOJ GEFs [cytosol] (Homo sapiens)
DOCK8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NF50 DOCK8
Gene Names
DOCK8
Chain
chain:1-2099
Reference Genes
BioGPS Gene:81704 DOCK8
COSMIC (genes):DOCK8 DOCK8
CTD Gene:81704 DOCK8
dbSNP Gene:81704 DOCK8
ENSEMBL:ENSG00000107099 DOCK8
ENSEMBL_homo_sapiens_GENE:ENSG00000107099.18 DOCK8
HGNC:19191 DOCK8
KEGG Gene (Homo sapiens):81704 DOCK8
Monarch:81704 DOCK8
NCBI Gene:81704 DOCK8
OMIM:611432 DOCK8
UCSC:Q8NF50 DOCK8
Reference Transcript
RefSeq:XM_011518048.2 DOCK8
RefSeq:NM_001190458.1 DOCK8
RefSeq:XM_011518045.2 DOCK8
RefSeq:XM_017015173.1 DOCK8
RefSeq:NM_001193536.1 DOCK8
RefSeq:XM_011518047.2 DOCK8
RefSeq:NM_203447.3 DOCK8
Other Identifiers
11733611_a_at
11733612_s_at
11745560_a_at
11746696_x_at
17082982
225502_PM_at
225502_at
232842_PM_at
232842_at
232843_PM_s_at
232843_s_at
239027_PM_at
239027_at
3159331
3159332
3159345
3159347
3159357
3159358
3159359
3159363
3159367
3159371
3159380
3159381
3159382
3159383
3159384
3159385
3159386
3159387
3159403
3159408
3159409
3159410
3159411
3159412
3159413
3159414
3159418
3159419
3159421
3159422
3159424
3159429
3159431
3159433
3159434
3159435
3159436
3159437
3159439
3159441
3159442
3159443
3159444
3159445
3159446
3159447
3159449
3159451
3159452
3159453
3159455
3159458
3159460
3159465
3159466
3159467
3159468
3159469
44632_at
49927_at
49932_g_at
54883_r_at
8153959
81704
82936_at
A_23_P353888
A_24_P331998
A_32_P181077
GE84251
GO:0001771
GO:0002376
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007155
GO:0007163
GO:0007264
GO:0012501
GO:0016020
GO:0023052
GO:0031252
GO:0031256
GO:0031258
GO:0036336
GO:0042995
GO:0043547
GO:0048870
GO:0051056
GO:0061485
GO:0070233
GO:0098772
GO:1903905
GO:1990869
GO:2000406
HMNXSV003021949
Hs.104308.0.A1_3p_at
Hs.171118.0.S1_3p_a_at
Hs.171118.0.S1_3p_at
Hs.171118.1.S1_3p_at
ILMN_1788931
PH_hs_0025524
TC09000004.hg
Participates
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
as a member of
RHOJ GEFs [cytosol] (Homo sapiens)
Inferred To
dock8 [cytosol]
(Xenopus tropicalis)
zizD [cytosol]
(Dictyostelium discoideum)
zizA [cytosol]
(Dictyostelium discoideum)
zizB [cytosol]
(Dictyostelium discoideum)
DOCK8 [cytosol]
(Bos taurus)
DOCK8 [cytosol]
(Caenorhabditis elegans)
DOCK8 [cytosol]
(Canis familiaris)
DOCK8 [cytosol]
(Gallus gallus)
DOCK8 [cytosol]
(Sus scrofa)
Zir [cytosol]
(Drosophila melanogaster)
Homologues of DOCK8 [cytosol]
(Dictyostelium discoideum)
zizC [cytosol]
(Dictyostelium discoideum)
Dock8 [cytosol]
(Mus musculus)
Dock8 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_011516350.1
,
XP_011516349.1
,
NP_982272.2
,
XP_016870662.1
,
XP_011516347.1
,
NP_001180465.1
,
NP_001177387.1
OpenTargets
ENSG00000107099
GeneCards
Q8NF50
HPA
ENSG00000107099-DOCK8
Ensembl
ENSP00000419438
,
ENSP00000394888
,
ENST00000432829
,
ENSG00000107099
,
ENST00000469391
,
ENST00000453981
,
ENSP00000408464
PRO
Q8NF50
Pharos - Targets
Q8NF50
Orphanet
18927
HMDB Protein
HMDBP08359
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.576
3
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