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DOCK9 [cytosol]
Stable Identifier
R-HSA-1012981
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dedicator of cytokinesis protein 9, DOCK9_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
DOCKs bind to RhoGEFs (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK9 [cytosol] (Homo sapiens)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
DOCK9 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
DOCK9 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK9 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BZ29 DOCK9
Gene Names
DOCK9, KIAA1058, ZIZ1
Chain
chain:1-2069
Reference Genes
BioGPS Gene:23348 DOCK9
COSMIC (genes):DOCK9 DOCK9
CTD Gene:23348 DOCK9
dbSNP Gene:23348 DOCK9
ENSEMBL:ENSG00000088387 DOCK9
HGNC:14132 DOCK9
Monarch:23348 DOCK9
NCBI Gene:23348 DOCK9
OMIM:607325 DOCK9
UCSC:Q9BZ29 DOCK9
Reference Transcript
RefSeq:NM_001130050.1 DOCK9
RefSeq:NM_015296.2 DOCK9
RefSeq:NM_001130049.1 DOCK9
RefSeq:NM_001318849.1 DOCK9
RefSeq:NM_001130048.1 DOCK9
Other Identifiers
11728453_a_at
11728454_s_at
11733577_a_at
11746257_a_at
11754880_x_at
16780509
212538_PM_at
212538_at
215041_PM_s_at
215041_s_at
215237_3p_at
215237_PM_at
215237_at
215238_PM_s_at
215238_s_at
23348
2811905
2811907
2811909
3522399
3522400
3522401
3522402
3522410
3522411
3522412
3522416
3522417
3522418
3522419
3522420
3522421
3522428
3522429
3522430
3522431
3522433
3522434
3522435
3522436
3522437
3522438
3522440
3522446
3522447
3522448
3522449
3522450
3522452
3522453
3522454
3522455
3522457
3522458
3522462
3522463
3522465
3522466
3522467
3522468
3522469
3522470
3522471
3522472
3522474
3522475
3522476
3522481
3522483
3522484
3522485
3522486
3522487
3522489
3522493
3522494
3522495
3522496
3522497
3522498
3522503
3522504
3522506
3522507
3522508
3522509
3522514
3522515
3522516
3522517
3522518
3522519
3522520
3522534
3522535
3522537
3522542
3522543
3522555
3522556
3522557
3522558
3522579
3522580
3522581
37571_at
55976_at
7972487
A_23_P162766
A_33_P3259817
A_33_P3259821
A_33_P3410279
A_33_P3410284
GE53719
GO:0005085
GO:0005515
GO:0005829
GO:0007264
GO:0008150
GO:0012505
GO:0016020
GO:0043547
GO:0045296
GO:0098772
HMNXSV003005364
HMNXSV003045791
HMNXSV003048380
HMNXSV003055122
Hs.307137.0.S1_3p_s_at
Hs.8021.0.S1_3p_at
Hs.8021.1.S1_3p_a_at
Hs.8021.1.S1_3p_at
ILMN_1773413
PH_hs_0024028
TC13000825.hg
Participates
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
as a member of
DOCK-GEFs [cytosol] (Homo sapiens)
Inferred To
Ziz [cytosol]
(Drosophila melanogaster)
zizD [cytosol]
(Dictyostelium discoideum)
DOCK9 [cytosol]
(Bos taurus)
DOCK9 [cytosol]
(Caenorhabditis elegans)
DOCK9 [cytosol]
(Canis familiaris)
DOCK9 [cytosol]
(Gallus gallus)
DOCK9 [cytosol]
(Sus scrofa)
Dock9 [cytosol]
(Mus musculus)
zizA [cytosol]
(Dictyostelium discoideum)
zizB [cytosol]
(Dictyostelium discoideum)
Homologues of DOCK9 [cytosol]
(Dictyostelium discoideum)
zizC [cytosol]
(Dictyostelium discoideum)
Cross References
ENSEMBL
ENST00000376460
,
ENSP00000487551
,
ENSP00000498761
,
ENST00000652315
,
ENSP00000365643
,
ENST00000627024
OpenTargets
ENSG00000088387
HPA
ENSG00000088387-DOCK9
PRO
Q9BZ29
Pharos - Targets
Q9BZ29
GlyGen
Q9BZ29
HMDB Protein
HMDBP08360
PDB
2WMO
,
1WG7
,
2WMN
,
2WM9
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009185)
p-S465,S467-SMAD2 [cytosol]
(R-HSA-3009186)
SMAD2 [cytosol]
(R-HSA-3006353)
p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009189)
Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-9773843)
SMAD2 [nucleoplasm]
(R-HSA-3006352)
p-S250-SMAD2 [cytosol]
(R-HSA-9731121)
SMAD2 Q429* [cytosol]
(R-HSA-9668727)
SMAD2 S467P [cytosol]
(R-HSA-3304375)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
0.576
3
UniProt:P84022 SMAD3
20
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
0.576
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.527
2
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