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CABLES1 [nucleoplasm]
Stable Identifier
R-HSA-1013870
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CDK5 and ABL1 enzyme substrate 1, CABL1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q00535
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)
CABLES1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Homo sapiens)
CABLES1 [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Cables1 links CDK2 and WEE1 (Homo sapiens)
CABLES1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TDN4 CABLES1
Gene Names
CABLES1, CABLES
Chain
chain:1-633
Reference Genes
BioGPS Gene:91768 CABLES1
COSMIC (genes):CABLES1 CABLES1
CTD Gene:91768 CABLES1
dbSNP Gene:91768 CABLES1
ENSEMBL:ENSG00000134508 CABLES1
ENSEMBL_homo_sapiens_GENE:ENSG00000134508.13 CABLES1
HGNC:25097 CABLES1
KEGG Gene (Homo sapiens):91768 CABLES1
Monarch:91768 CABLES1
NCBI Gene:91768 CABLES1
OMIM:609194 CABLES1
UCSC:Q8TDN4 CABLES1
Reference Transcript
RefSeq:NM_001100619.2 CABLES1
RefSeq:NM_001256438.1 CABLES1
RefSeq:NM_138375.2 CABLES1
Other Identifiers
11732905_a_at
11739575_a_at
11751156_a_at
11754455_a_at
16851427
225531_PM_at
225531_at
225532_PM_at
225532_at
3781541
3781543
3781544
3781545
3781546
3781547
3781560
3781561
3781566
3781576
3781583
3781596
3781597
3781599
3781609
3781610
3781612
3781613
3781614
3781615
3781616
3781624
48558_at
72819_r_at
77248_at
8020495
91768
A_14_P106670
A_14_P112719
A_23_P422851
GE56999
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0007049
GO:0007399
GO:0043226
GO:0048856
GO:0051301
GO:0051726
HMNXSV003025348
Hs.17901.0.S1_3p_at
Hs.17901.0.S2_3p_at
ILMN_1653001
PH_hs_0001608
TC18000099.hg
TC18000653.hg
Participates
as a component of
CDK2:CABLES1:WEE1 [nucleoplasm] (Homo sapiens)
as an input of
Cables1 links CDK2 and WEE1 (Homo sapiens)
This entity regulates
Positively
Phosphorylation of Cyclin A:Cdk2 at Tyr 15
(Homo sapiens)
Phosphorylation of Cyclin E:CDK2 complexes by WEE1
(Homo sapiens)
Other forms of this molecule
CABLES1 [cytosol]
Inferred To
cables1 [nucleoplasm]
(Xenopus tropicalis)
Cables1 [nucleoplasm]
(Mus musculus)
Cables1 [nucleoplasm]
(Rattus norvegicus)
Dmel\CG6191 [nucleoplasm]
(Drosophila melanogaster)
si:dkey-2p18.3 [nucleoplasm]
(Danio rerio)
CABLES1 [nucleoplasm]
(Bos taurus)
CABLES1 [nucleoplasm]
(Canis familiaris)
CABLES1 [nucleoplasm]
(Gallus gallus)
CABLES1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_612384.1
,
NP_001094089.1
,
NP_001243367.1
OpenTargets
ENSG00000134508
HPA
ENSG00000134508-CABLES1
GeneCards
Q8TDN4
Ensembl
ENSG00000134508
,
ENSP00000383321
,
ENST00000420687
,
ENSP00000413851
,
ENST00000400473
,
ENSP00000256925
,
ENST00000256925
PRO
Q8TDN4
Pharos - Targets
Q8TDN4
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.848
7
UniProt:Q9H3D4-1 TP63
0.471
7
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