Reactome | IRF5 [cytosol]

IRF5 [cytosol]

Stable Identifier

R-HSA-1015676

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Interferon regulatory factor 5, IRF5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13568 IRF5

Gene Names

IRF5

Chain

chain:1-498

Reference Genes

BioGPS Gene:3663 IRF5

COSMIC (genes):IRF5 IRF5

CTD Gene:3663 IRF5

dbSNP Gene:3663 IRF5

ENSEMBL:ENSG00000128604 IRF5

ENSEMBL_homo_sapiens_GENE:ENSG00000128604.21 IRF5

HGNC:6120 IRF5

KEGG Gene (Homo sapiens):3663 IRF5

Monarch:3663 IRF5

NCBI Gene:3663 IRF5

OMIM:607218 IRF5

UCSC:Q13568 IRF5

Reference Transcript

Other Identifiers

11726685_a_at

11726686_a_at

11726687_a_at

11746801_x_at

11752974_a_at

17051347

205468_PM_s_at

205468_s_at

205469_PM_s_at

205469_s_at

239412_PM_at

239412_at

3023247

3023250

3023252

3023253

3023254

3023256

3023258

3023259

3023260

3023261

3023262

3023263

3023264

36465_at

3663

477_at

478_g_at

8136045

A_14_P120116

A_23_P500271

A_24_P363609

GE59217

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001228

GO:0002376

GO:0002720

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006954

GO:0012501

GO:0019221

GO:0019901

GO:0023052

GO:0032481

GO:0032494

GO:0032495

GO:0032727

GO:0032728

GO:0032735

GO:0042802

GO:0043065

GO:0043226

GO:0043565

GO:0045087

GO:0045944

GO:0051607

GO:0098542

GO:0098586

GO:0140110

GO:1990837

HMNXSV003027868

Hs.232644.0.A1_3p_at

Hs.54434.0.S1_3p_a_at

ILMN_1670576

ILMN_2312606

PH_hs_0016421

TC07000789.hg

U51127_at

g4504726_3p_a_at

Participates

as an input of

TASL recruits IRF5 (Homo sapiens)

as a component of

SLC15A4:p-S-TASL:IRF5 [endolysosome membrane] (Homo sapiens)

as a member of

IRF 1-9 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S446-IRF5 [nucleoplasm]

p-S446-IRF5 [cytosol]

Inferred To

Irf5 [cytosol] (Mus musculus)

Irf5 [cytosol] (Rattus norvegicus)

IRF5 [cytosol] (Bos taurus)

IRF5 [cytosol] (Gallus gallus)

IRF5 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_011514460.1, NP_001229381.1, XP_011514465.1, NP_001334857.1, NP_001092099.1, XP_011514461.1, XP_011514466.1, XP_011514462.1, XP_011514463.1, NP_116032.1, XP_005250374.1, XP_006716037.1, NP_001092097.2, NP_001092100.1, XP_011514464.1

OpenTargets

ENSG00000128604

HPA

ENSG00000128604-IRF5

GeneCards

Q13568

Ensembl

ENST00000402030, ENSP00000419950, ENSG00000128604, ENSP00000418037, ENSP00000419149, ENSP00000418534, ENST00000477535, ENST00000357234, ENST00000473745, ENSP00000349770, ENST00000489702, ENSP00000385352, ENST00000465603

PRO

Q13568

Pharos - Targets

Q13568

Orphanet

19316

PDB

3DSH

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.656	6
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.618	3
UniProt:Q13568 IRF5	3	p-S446-IRF5 [nucleoplasm] (R-HSA-9860304) p-S446-IRF5 [cytosol] (R-HSA-9860271) IRF5 [cytosol] (R-HSA-1015676)	0.618	3
UniProt:O94986 CEP152	1	CEP152 [cytosol] (R-HSA-380277)	0.574	3
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.543	3
UniProt:Q13263 TRIM28	3	SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600) TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867)	0.524	5
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.499	2
UniProt:Q8N697 SLC15A4	4	SLC15A4 [plasma membrane] (R-HSA-6800447) SLC15A4 [specific granule membrane] (R-HSA-6799715) SLC15A4 [endolysosome membrane] (R-HSA-9860282) SLC15A4 [lysosomal membrane] (R-HSA-428039)	0.462	2

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