Reactome | KIF23 [cytosol]

KIF23 [cytosol]

Stable Identifier

R-HSA-1015863

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MKLP1, Kinesin-like protein KIF23

Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        Kinesin-6 [cytosol] (Homo sapiens)
        
        KIF23 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        Kinesin-6 [cytosol] (Homo sapiens)
        
        KIF23 [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        Kinesin-6 [cytosol] (Homo sapiens)
        
        KIF23 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        Kinesin-6 [cytosol] (Homo sapiens)
        
        KIF23 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q02241 KIF23

Gene Names

KIF23, KNSL5, MKLP1

Chain

chain:1-960

Reference Genes

BioGPS Gene:9493 KIF23

COSMIC (genes):KIF23 KIF23

CTD Gene:9493 KIF23

dbSNP Gene:9493 KIF23

ENSEMBL:ENSG00000137807 KIF23

HGNC:6392 KIF23

KEGG:hsa:9493 KIF23

Monarch:9493 KIF23

NCBI Gene:9493 KIF23

OMIM:605064 KIF23

UCSC:Q02241 KIF23

Reference Transcript

Participates

as a member of

Kinesin-6 [cytosol] (Homo sapiens)

Other forms of this molecule

KIF23 [nucleoplasm]

p-S911,S912-KIF23 [nucleoplasm]

Inferred To

Kif23 [cytosol] (Mus musculus)

Kif23 [cytosol] (Rattus norvegicus)

pav [cytosol] (Drosophila melanogaster)

KIF23 [cytosol] (Bos taurus)

KIF23 [cytosol] (Canis familiaris)

KIF23 [cytosol] (Gallus gallus)

KIF23 [cytosol] (Sus scrofa)

zen-4 [cytosol] (Caenorhabditis elegans)

kif23 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_612565.1, NP_004847.2

OpenTargets

ENSG00000137807

ENSEMBL

ENST00000260363, ENSG00000137807, ENST00000352331, ENSP00000497065, ENSP00000260363, ENST00000647715, ENSP00000304978

HPA

ENSG00000137807-KIF23

GeneCards

KIF23

ZINC - Substances

KIF23_HUMAN

ZINC target

Q02241

PRO

Q02241

Pharos - Targets

Q02241

Orphanet

KIF23

GlyGen

Q02241

PDB

3VHX

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.923	10
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.922	16
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.918	11
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.901	9
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.886	9
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.859	8
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.667	23
UniProt:P62331	2	Arf6 [cytosol] (R-MMU-8871121) Arf6 [recycling endosome membrane] (R-MMU-2029049)	0.66	10
UniProt:Q7RTP6-1 MICAL3			0.576	8
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.569	4
UniProt:Q9JLQ0 Cd2ap	1	CD2AP_MOUSE [cytosol] (R-MMU-451711)	0.564	2
UniProt:Q9Z179 SHCBP			0.564	2
UniProt:Q9WVM1	1	Racgap1 [cytosol] (R-MMU-195122)	0.564	2
UniProt:Q9H8V3 ECT2	1	ECT2 [cytosol] (R-HSA-195036)	0.564	2
UniProt:Q9NR09 BIRC6	2	BIRC6(1-958)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713450) BIRC6(1-958)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713451)	0.556	4
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	4
UniProt:Q9HAF1 MEAF6	1	MEAF6 [nucleoplasm] (R-HSA-3318448)	0.527	2
UniProt:Q8NEM2 SHCBP			0.527	2
UniProt:Q7RTP6 MICA3			0.491	2