Reactome | FUT8 [Golgi membrane]

FUT8 [Golgi membrane]

Stable Identifier

R-HSA-1028782

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Alpha-1,6-fucosyltransferase 8, FUT8_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike trimer glycoside chains get additional branches (Homo sapiens)
        
        FUT8 [Golgi membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Homo sapiens)
        
        FUT8 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BYC5 FUT8

Gene Names

FUT8

Chain

chain:1-575

Reference Genes

BioGPS Gene:2530 FUT8

COSMIC (genes):FUT8 FUT8

CTD Gene:2530 FUT8

dbSNP Gene:2530 FUT8

ENSEMBL:ENSG00000033170 FUT8

ENSEMBL_homo_sapiens_GENE:ENSG00000033170.17 FUT8

HGNC:4019 FUT8

KEGG Gene (Homo sapiens):2530 FUT8

Monarch:2530 FUT8

NCBI Gene:2530 FUT8

OMIM:602589 FUT8

UCSC:Q9BYC5 FUT8

Reference Transcript

Other Identifiers

11741568_a_at

11749723_a_at

1554930_PM_a_at

1554930_a_at

16785483

203988_PM_s_at

203988_s_at

2530

3540553

3540554

3540555

3540561

3540572

3540573

3540574

3540575

3540585

3540586

3540592

3540605

3540606

3540614

3540616

3540618

3540623

3540624

3540625

3540626

3540627

3540628

41628_at

42282_at

7975136

A_14_P109106

A_14_P113075

A_23_P313632

D89289_at

GE60337

GO:0000139

GO:0001701

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005794

GO:0005975

GO:0006486

GO:0006487

GO:0006491

GO:0007179

GO:0007229

GO:0007585

GO:0008424

GO:0009312

GO:0010468

GO:0010761

GO:0016020

GO:0016477

GO:0016740

GO:0016757

GO:0016758

GO:0017124

GO:0018279

GO:0019082

GO:0023052

GO:0032580

GO:0036071

GO:0036211

GO:0042355

GO:0043112

GO:0043226

GO:0046368

GO:0046921

GO:0048856

GO:0048870

GO:0055086

GO:0070062

GO:0140096

GO:1900407

GO:1901135

HMNXSV003010961

Hs2.118722.3.S1_3p_s_at

ILMN_1741422

PH_hs_0006549

TC14000397.hg

TC14001735.hg

g4758407_3p_a_at

p33676

Inferred To

FUT8 [Golgi membrane] (Bos taurus)

FUT8 [Golgi membrane] (Canis familiaris)

FUT8 [Golgi membrane] (Danio rerio)

FUT8 [Golgi membrane] (Gallus gallus)

FUT8 [Golgi membrane] (Sus scrofa)

FucT6 [Golgi membrane] (Drosophila melanogaster)

Fut8 [Golgi membrane] (Mus musculus)

Fut8 [Golgi membrane] (Rattus norvegicus)

fut-8 [Golgi membrane] (Caenorhabditis elegans)

fut8 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_004471.4, NP_835369.1, NP_835368.1

OpenTargets

ENSG00000033170

HPA

ENSG00000033170-FUT8

GeneCards

Q9BYC5

Ensembl

ENST00000342677, ENSG00000033170, ENSP00000378087, ENSP00000501213, ENSP00000353910, ENST00000394586, ENSP00000452433, ENST00000557164, ENST00000360689, ENST00000673929, ENSP00000345865

PRO

Q9BYC5

Pharos - Targets

Q9BYC5

Orphanet

27600

HMDB Protein

HMDBP05922

PDB

6X5U, 6X5R, 6X5H, 6VLE, 2DE0, 6VLD, 6X5T, 6X5S

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96DT7-3 ZBTB10			0.556	3
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2