Reactome | FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP

FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP

Stable Identifier

R-HSA-1028788

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

Synonyms

Addition of alpha 1,6 fucose to the first GlcNAc of the N-glycan

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Homo sapiens)

General

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FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Addition of a fucose moiety as an alpha 1-6 linkage to the first GlcNAc residue of the N-glycan (Clarke JL, Watkins WM 1999; Yamaguchi Y et al, 1999; Yamaguchi Y et al 2000).

Literature References

PubMed ID	Title	Journal	Year
10343104	Mapping of the alpha-1,6-fucosyltransferase gene, FUT8, to human chromosome 14q24.3 Fujii, J, Miyoshi, O, Uozumi, N, Yamaguchi, Y, Ikeda, Y, Inoue, S, Yanagidani, S, Niikawa, N, Taniguchi, N, Egashira, M	Cytogenet Cell Genet	1999
10814706	Genomic structure and promoter analysis of the human alpha1, 6-fucosyltransferase gene (FUT8) Fujii, J, Uozumi, N, Ihara, H, Inoue, S, Ikeda, Y, Yanagidani, S, Takahashi, T, Taniguchi, N, Yamaguchi, Y, Sasho, C, Tanaka, T	Glycobiology	2000
9949196	Expression of human alpha-l-fucosyltransferase gene homologs in monkey kidney COS cells and modification of potential fucosyltransferase acceptor substrates by an endogenous glycosidase Watkins, WM, Clarke, JL	Glycobiology	1999