Expression of interferon-beta

Stable Identifier
R-HSA-1028812
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Expression of interferon-beta
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The IFN-beta genes are transcribed and translated yielding IFNB proteins which are secreted. This process is positively regulated by IRF3:CBP/p300 transcription factor complex.
Literature References
PubMed ID Title Journal Year
11244049 IRF family of transcription factors as regulators of host defense

Ogasawara, K, Takaoka, A, Tanaka, N, Taniguchi, T

Annu Rev Immunol 2001
20627800 Regulation of immune cell homeostasis by type I interferons

Tough, DF, Mattei, F, Schiavoni, G

Cytokine Growth Factor Rev 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300:Promotor region of interferon beta [nucleoplasm] (Homo sapiens)
Active Unit
p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 [nucleoplasm]
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-11-18)
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