Dimerization of Phospho IRF3 or phospho IRF7

Stable Identifier
R-HSA-1028821
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of these transcription factors IRF3 and IRF7 results in a conformational change that allows their dimerization to form homo- or hetero dimers. Each of the three different combinations of dimers (IRF3:IRF3, IRF7:IRF7 and IRF3:IRF7) may selectively effect the transcription of IFN-alpha gene subfamilies and IFN-beta genes.

Literature References
PubMed ID Title Journal Year
12604599 Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators

Yang, H, Lin, CH, Ma, G, Baffi, MO, Wathelet, MG

J Biol Chem 2003
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