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CD44 [plasma membrane]
Stable Identifier
R-HSA-1031688
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CD44 antigen, CD44_HUMAN, Hyaluronate receptor
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
MMP2, MMP7, MMP9 bind CD44 (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
CD44:MMP2, MMP7, MMP9 [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
SPP1 (osteopontin) binds CD44 (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
SPP1:CD44 [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
E-selectin binds E-selectin ligand (Homo sapiens)
2xSELE ligands:SELE [plasma membrane] (Homo sapiens)
SELE ligands [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
SELE ligands [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Expression of IFNG-stimulated genes (Homo sapiens)
IFN-gamma upregulated CAMs [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule membrane proteins (Homo sapiens)
Secretory granule membrane proteins [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Hyaluronan metabolism (Homo sapiens)
Hyaluronan uptake and degradation (Homo sapiens)
HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Homo sapiens)
HA:HAR:HYAL2 [plasma membrane] (Homo sapiens)
HARs [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane] (Homo sapiens)
HA:HAR:HYAL2 [plasma membrane] (Homo sapiens)
HARs [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Homo sapiens)
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane] (Homo sapiens)
HA:HAR:HYAL2 [plasma membrane] (Homo sapiens)
HARs [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
Receptor-mediated uptake of HA (Homo sapiens)
HA:HAR:HYAL2 [plasma membrane] (Homo sapiens)
HARs [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
HARs [plasma membrane] (Homo sapiens)
CD44 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16070 CD44
Gene Names
CD44, LHR, MDU2, MDU3, MIC4
Chain
signal peptide:1-20, chain:21-742
Reference Genes
BioGPS Gene:960 CD44
COSMIC (genes):CD44 CD44
CTD Gene:960 CD44
dbSNP Gene:960 CD44
ENSEMBL:ENSG00000026508 CD44
HGNC:1681 CD44
KEGG Gene (Homo sapiens):960 CD44
Monarch:960 CD44
NCBI Gene:960 CD44
OMIM:107269 CD44
UCSC:P16070 CD44
Reference Transcript
RefSeq:NM_001202555.1 CD44
RefSeq:NM_000610.3 CD44
RefSeq:NM_001202557.1 CD44
RefSeq:NM_001001389.1 CD44
RefSeq:NM_001001390.1 CD44
RefSeq:XM_011520488.1 CD44
RefSeq:NM_001202556.1 CD44
RefSeq:NM_001001392.1 CD44
RefSeq:NM_001001391.1 CD44
Other Identifiers
0000510390
1125_s_at
1126_s_at
11715915_a_at
11715916_a_at
11715917_a_at
11739617_x_at
11742043_a_at
11744654_s_at
11750189_s_at
11750190_x_at
11753291_a_at
11753292_x_at
1557905_3p_s_at
1557905_s_at
16723614
2036_s_at
204489_s_at
204490_s_at
209835_x_at
210916_s_at
212014_x_at
212063_at
31472_s_at
3326636
3326637
3326652
3326653
3326658
3326664
3326666
3326667
3326668
3326669
3326683
3326686
3326694
3326696
3326700
3326705
3326711
3326712
3326714
3326717
3326720
3326721
3326722
3326726
3326727
3326728
3326729
40493_at
7939341
960
A_14_P108079
A_14_P114193
A_23_P24870
A_33_P3294509
GE59805
GE80929
GO:0000902
GO:0002376
GO:0003674
GO:0004888
GO:0004896
GO:0005515
GO:0005518
GO:0005540
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0005887
GO:0005902
GO:0005925
GO:0006464
GO:0006810
GO:0006950
GO:0006954
GO:0007155
GO:0007160
GO:0007165
GO:0008150
GO:0008219
GO:0009056
GO:0009986
GO:0016020
GO:0016021
GO:0016192
GO:0016323
GO:0016324
GO:0016477
GO:0022617
GO:0030198
GO:0030214
GO:0030667
GO:0031258
GO:0031410
GO:0032991
GO:0033138
GO:0034116
GO:0035692
GO:0040011
GO:0042110
GO:0042995
GO:0043066
GO:0043154
GO:0043167
GO:0043226
GO:0043312
GO:0043518
GO:0044281
GO:0044319
GO:0044344
GO:0048856
GO:0048870
GO:0050731
GO:0050900
GO:0051216
GO:0060333
GO:0070062
GO:0070374
GO:0070487
GO:0098609
GO:1900625
GO:1902166
GO:2000392
Hs.323950.2.A1_3p_at
Hs2.423212.1.S1_3p_s_at
ILMN_1732193
ILMN_1778625
ILMN_1803429
ILMN_2348788
PH_hs_0032595
TC11000332.hg
g10835162_3p_a_at
g13325117_3p_a_at
g180196_3p_s_at
Participant Of
hasMember
HARs [plasma membrane]
IFN-gamma upregulated CAMs [plasma membrane]
Secretory granule membrane proteins [plasma membrane]
SELE ligands [plasma membrane]
hasComponent
CD44:MMP2, MMP7, MMP9 [plasma membrane]
SPP1:CD44 [plasma membrane]
input
MMP2, MMP7, MMP9 bind CD44
SPP1 (osteopontin) binds CD44
Other forms of this molecule
CD44 [secretory granule membrane]
Inferred To
Cd44 [plasma membrane] (Mus musculus)
Cd44 [plasma membrane] (Rattus norvegicus)
CD44 [plasma membrane] (Gallus gallus)
CD44 [plasma membrane] (Sus scrofa)
cd44 [plasma membrane] (Xenopus tropicalis)
cd44b [plasma membrane] (Danio rerio)
Cross References
RefSeq
XP_011518790.1
,
NP_001001389.1
,
NP_000601.3
,
NP_001189485.1
,
NP_001001391.1
,
NP_001189486.1
,
NP_001001392.1
,
NP_001001390.1
,
NP_001189484.1
OpenTargets
ENSG00000026508
GeneCards
P16070
HPA
ENSG00000026508-CD44
ZINC target
P16070
Ensembl
ENSP00000263398
,
ENST00000428726
,
ENSP00000389830
,
ENST00000415148
,
ENSP00000398632
,
ENST00000278386
,
ENSP00000404447
,
ENSG00000026508
,
ENSP00000309732
,
ENSP00000278386
,
ENSP00000392331
,
ENST00000263398
,
ENST00000434472
,
ENST00000433892
,
ENST00000352818
PRO
P16070
HMDB Protein
HMDBP01716
PDB
1UUH
,
6TXS
,
1POZ
,
4PZ4
,
4PZ3
,
2I83
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18011 IPAB
0.632
4
UniProt:P10451 SPP1
5
SPP1 [endoplasmic reticulum lumen]
(R-HSA-8956713)
SPP1 [extracellular region]
(R-HSA-215967)
p-SPP1 [endoplasmic reticulum lumen]
(R-HSA-8956883)
SPP1(17-?) [extracellular region]
(R-HSA-4093351)
SPP1(?-314) [extracellular region]
(R-HSA-4093349)
0.621
4
ganglioside GM1 [ChEBI:61048]
2
GM1 [lysosomal membrane]
(R-ALL-1605677)
GM1 [external side of plasma membrane]
(R-ALL-8850300)
0.556
3
hyaluronic acid [ChEBI:16336]
3
HUA [extracellular region]
(R-ALL-1297302)
HUA [endocytic vesicle lumen]
(R-ALL-2239419)
HUA [cytosol]
(R-ALL-877209)
0.544
2
UniProt:Q9UPY5 SLC7A11
1
SLC7A11 [plasma membrane]
(R-HSA-378515)
0.537
4
UniProt:P26038 MSN
1
MSN [cytosol]
(R-HSA-437350)
0.463
6
UniProt:P04233 CD74
13
CD74(81-104) [lysosomal membrane]
(R-HSA-2130446)
CD74(81-104) [lysosomal lumen]
(R-HSA-2213220)
CD74(1-117) [lysosomal membrane]
(R-HSA-2130632)
CD74 [transport vesicle membrane]
(R-HSA-2130624)
CD74 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130522)
CD74 [endocytic vesicle membrane]
(R-HSA-2130460)
CD74 [ER to Golgi transport vesicle membrane]
(R-HSA-2130456)
CD74 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-1181241)
CD74 [Golgi membrane]
(R-HSA-2214388)
CD74 [trans-Golgi network membrane]
(R-HSA-2130493)
CD74(1-176) [lysosomal membrane]
(R-HSA-2130602)
CD74 [lysosomal membrane]
(R-HSA-2130320)
CD74 [plasma membrane]
(R-HSA-2130666)
0.463
9
UniProt:P21926 CD9
4
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.462
2
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