Reactome | CD44 [plasma membrane]

CD44 [plasma membrane]

Stable Identifier

R-HSA-1031688

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CD44 antigen, CD44_HUMAN, Hyaluronate receptor

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P16070 CD44

Gene Names

CD44, LHR, MDU2, MDU3, MIC4

Chain

signal peptide:1-20, chain:21-742

Reference Genes

BioGPS Gene:960 CD44

COSMIC (genes):CD44 CD44

CTD Gene:960 CD44

dbSNP Gene:960 CD44

ENSEMBL:ENSG00000026508 CD44

HGNC:1681 CD44

KEGG Gene (Homo sapiens):960 CD44

Monarch:960 CD44

NCBI Gene:960 CD44

OMIM:107269 CD44

UCSC:P16070 CD44

Reference Transcript

Other Identifiers

0000510390

1125_s_at

1126_s_at

11715915_a_at

11715916_a_at

11715917_a_at

11739617_x_at

11742043_a_at

11744654_s_at

11750189_s_at

11750190_x_at

11753291_a_at

11753292_x_at

1557905_3p_s_at

1557905_s_at

16723614

2036_s_at

204489_s_at

204490_s_at

209835_x_at

210916_s_at

212014_x_at

212063_at

31472_s_at

3326636

3326637

3326652

3326653

3326658

3326664

3326666

3326667

3326668

3326669

3326683

3326686

3326694

3326696

3326700

3326705

3326711

3326712

3326714

3326717

3326720

3326721

3326722

3326726

3326727

3326728

3326729

40493_at

7939341

960

A_14_P108079

A_14_P114193

A_23_P24870

A_33_P3294509

GE59805

GE80929

GO:0000902

GO:0002376

GO:0003674

GO:0004888

GO:0004896

GO:0005515

GO:0005518

GO:0005540

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0005887

GO:0005902

GO:0005925

GO:0006464

GO:0006810

GO:0006950

GO:0006954

GO:0007155

GO:0007160

GO:0007165

GO:0008150

GO:0008219

GO:0009056

GO:0009986

GO:0016020

GO:0016021

GO:0016192

GO:0016323

GO:0016324

GO:0016477

GO:0022617

GO:0030198

GO:0030214

GO:0030667

GO:0031258

GO:0031410

GO:0032991

GO:0033138

GO:0034116

GO:0035692

GO:0040011

GO:0042110

GO:0042995

GO:0043066

GO:0043154

GO:0043167

GO:0043226

GO:0043312

GO:0043518

GO:0044281

GO:0044319

GO:0044344

GO:0048856

GO:0048870

GO:0050731

GO:0050900

GO:0051216

GO:0060333

GO:0070062

GO:0070374

GO:0070487

GO:0098609

GO:1900625

GO:1902166

GO:2000392

Hs.323950.2.A1_3p_at

Hs2.423212.1.S1_3p_s_at

ILMN_1732193

ILMN_1778625

ILMN_1803429

ILMN_2348788

PH_hs_0032595

TC11000332.hg

g10835162_3p_a_at

g13325117_3p_a_at

g180196_3p_s_at

Participant Of

hasMember

hasComponent

input

Other forms of this molecule

CD44 [secretory granule membrane]

Inferred To

Cd44 [plasma membrane] (Mus musculus)

Cd44 [plasma membrane] (Rattus norvegicus)

CD44 [plasma membrane] (Gallus gallus)

CD44 [plasma membrane] (Sus scrofa)

cd44 [plasma membrane] (Xenopus tropicalis)

cd44b [plasma membrane] (Danio rerio)

Cross References

RefSeq

XP_011518790.1, NP_001001389.1, NP_000601.3, NP_001189485.1, NP_001001391.1, NP_001189486.1, NP_001001392.1, NP_001001390.1, NP_001189484.1

OpenTargets

ENSG00000026508

GeneCards

P16070

HPA

ENSG00000026508-CD44

ZINC target

P16070

Ensembl

ENSP00000263398, ENST00000428726, ENSP00000389830, ENST00000415148, ENSP00000398632, ENST00000278386, ENSP00000404447, ENSG00000026508, ENSP00000309732, ENSP00000278386, ENSP00000392331, ENST00000263398, ENST00000434472, ENST00000433892, ENST00000352818

PRO

P16070

HMDB Protein

HMDBP01716

PDB

1UUH, 6TXS, 1POZ, 4PZ4, 4PZ3, 2I83

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18011 IPAB			0.632	4
UniProt:P10451 SPP1	5	SPP1 [endoplasmic reticulum lumen] (R-HSA-8956713) SPP1 [extracellular region] (R-HSA-215967) p-SPP1 [endoplasmic reticulum lumen] (R-HSA-8956883) SPP1(17-?) [extracellular region] (R-HSA-4093351) SPP1(?-314) [extracellular region] (R-HSA-4093349)	0.621	4
ganglioside GM1 [ChEBI:61048]	2	GM1 [lysosomal membrane] (R-ALL-1605677) GM1 [external side of plasma membrane] (R-ALL-8850300)	0.556	3
hyaluronic acid [ChEBI:16336]	3	HUA [extracellular region] (R-ALL-1297302) HUA [endocytic vesicle lumen] (R-ALL-2239419) HUA [cytosol] (R-ALL-877209)	0.544	2
UniProt:Q9UPY5 SLC7A11	1	SLC7A11 [plasma membrane] (R-HSA-378515)	0.537	4
UniProt:P26038 MSN	1	MSN [cytosol] (R-HSA-437350)	0.463	6
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.463	9
UniProt:P21926 CD9	4	CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [plasma membrane] (R-HSA-51717) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2