Reactome | MT2A [cytosol]

MT2A [cytosol]

Stable Identifier

R-HSA-1031707

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Metallothionein-2, MT2_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P09429 HMGB1

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External Reference Information

External Reference

UniProt:P02795 MT2A

Gene Names

MT2A, CES1, MT2

Chain

chain:1-61

Reference Genes

BioGPS Gene:4502 MT2A

COSMIC (genes):MT2A MT2A

CTD Gene:4502 MT2A

dbSNP Gene:4502 MT2A

ENSEMBL:ENSG00000125148 MT2A

ENSEMBL_homo_sapiens_GENE:ENSG00000125148.7 MT2A

HGNC:7406 MT2A

KEGG Gene (Homo sapiens):4502 MT2A

Monarch:4502 MT2A

NCBI Gene:4502 MT2A

OMIM:156360 MT2A

UCSC:P02795 MT2A

Reference Transcript

RefSeq:NM_005953.3 MT2A

Other Identifiers

11753900_x_at

11758729_x_at

16819207

212185_PM_x_at

212185_x_at

2405333

2729820

2729855

2729857

3662109

3662113

3662116

3662117

3662255

4502

7995783

8162531

A_23_P106844

A_24_P361896

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006878

GO:0006882

GO:0008270

GO:0010035

GO:0010273

GO:0036016

GO:0036018

GO:0043226

GO:0045926

GO:0046872

GO:0055065

GO:0070887

GO:0071276

GO:0071280

GO:0071294

GO:0098754

HMNXSV003026798

Hs.118786.0.S1_3p_at

PH_hs_0038876

TC16002034.hg

V00594_s_at

Participates

as a component of

as an input of

as an output of

Expression of IFNG-stimulated genes (Homo sapiens)

Inferred To

MT1A [cytosol] (Bos taurus)

MT1A [cytosol] (Canis familiaris)

MT1A [cytosol] (Danio rerio)

MT1A [cytosol] (Gallus gallus)

MT1A [cytosol] (Rattus norvegicus)

MT1A [cytosol] (Sus scrofa)

Mt2 [cytosol] (Mus musculus)

Cross References

RefSeq

NP_005944.1

OpenTargets

ENSG00000125148

HPA

ENSG00000125148-MT2A

GeneCards

P02795

Ensembl

ENSP00000245185, ENSG00000125148, ENST00000245185

PRO

P02795

Pharos - Targets

P02795

PDB

1MHU, 2MHU

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P58062 ISK7			0.704	7
UniProt:Q15139 PRKD1	1	PRKD1 [cytosol] (R-HSA-58210)	0.592	7
UniProt:P31153 MAT2A	1	MAT2A [cytosol] (R-HSA-174363)	0.556	3
UniProt:P14678-2 SNRPB			0.556	3
UniProt:P21333-2 FLNA			0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:Q96A83-2 Q96A832			0.556	3
UniProt:Q9UMF0 ICAM5	1	ICAM5 [plasma membrane] (R-HSA-197684)	0.556	3
UniProt:Q9BVL2 NUP58			0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:O14901 KLF11			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE-4 [extracellular region] (R-HSA-9711070) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [extracellular region] (R-HSA-174646) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P09429 HMGB1	5	HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [nucleoplasm] (R-HSA-266221) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422)	0.553	2
UniProt:Q8TE69 EOLA1			0.508	2
UniProt:Q13585 MTR1L			0.471	2

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