GAF binds the GAS promoter elements in the IFNG-regulated genes

Stable Identifier
R-HSA-1031713
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

GAF transcription factor translocated into nucleus binds to defined DNA sequence called GAS (gamma activated sequence) elements in the promoters of IFN-gamma responsive elements and initiate transcription.

Literature References
PubMed ID Title Journal Year
1901265 Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor

Decker, T, Lew, DJ, Mirkovitch, J, Darnell JE, Jr

EMBO J 1991
1898761 Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons

Lew, DJ, Decker, T, Strehlow, I, Darnell, JE

Mol Cell Biol 1991
1281555 Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein

Shuai, K, Schindler, C, Prezioso, VR, Darnell JE, Jr

Science 1992
9143706 Cellular responses to interferon-gamma

Boehm, U, Klamp, T, Groot, M, Howard, JC

Annu Rev Immunol 1997
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