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IL6R-2 [extracellular region]
Stable Identifier
R-HSA-1067661
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
sIL6R, Interleukin-6 receptor subunit alpha short soluble form, IL6RA_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
Assembly of hexameric IL-6 receptor (Homo sapiens)
IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
IL6 binds IL6R-2 (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
IL6ST is tyrosine phosphorylated (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
JAK activation (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
PTPN11 binds CBL (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
PTPN11 binds p-Y759-IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
PTPN11 is phosphorylated (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Phosphorylated STATs are released (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
SOCS3 binds IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Serine phosphorylation of STATs (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
MAPK1 (ERK2) activation (Homo sapiens)
MAP2K2 binds MAPK1 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
MAPK3 (ERK1) activation (Homo sapiens)
MAP2K1 binds MAPK3 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6R-2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08887-2 IL6R
Gene Names
IL6R
Other Identifiers
11736509_x_at
11736510_a_at
11741958_a_at
11741959_x_at
160032_at
16671457
205945_PM_at
205945_at
217489_PM_s_at
217489_s_at
226333_PM_at
226333_at
2360258
2360259
2360260
2360268
2360269
2360271
2360272
2360273
2360274
2360275
2360277
2360281
2360282
2360286
2360287
2360288
2360289
2360290
2360291
2360292
3570
48565_at
7905789
985_s_at
A_14_P131110
A_21_P0000171
A_24_P379413
A_33_P3288844
GE79044
GE85597
GO:0002376
GO:0002384
GO:0002446
GO:0002548
GO:0002690
GO:0004896
GO:0004897
GO:0004915
GO:0004921
GO:0005138
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005896
GO:0006953
GO:0006954
GO:0008284
GO:0009897
GO:0010536
GO:0010573
GO:0012501
GO:0016020
GO:0016324
GO:0019221
GO:0019899
GO:0019970
GO:0019981
GO:0023052
GO:0030154
GO:0031018
GO:0032717
GO:0032722
GO:0032755
GO:0032966
GO:0034097
GO:0036211
GO:0038154
GO:0042531
GO:0042803
GO:0043235
GO:0043410
GO:0045669
GO:0048661
GO:0048856
GO:0048870
GO:0050731
GO:0050829
GO:0050830
GO:0060089
GO:0070102
GO:0070110
GO:0070119
GO:0070120
GO:0072126
GO:0072540
GO:0097191
GO:0098542
HMNXSV003028760
HMNXSV003049892
Hs.17998.0.S1_3p_at
Hs.193400.1.S1_3p_a_at
ILMN_1696394
ILMN_1754753
M20566_at
PH_hs_0011409
TC01001276.hg
X58298_s_at
g4504672_3p_at
Participates
as an input of
IL6 binds IL6R-2 (Homo sapiens)
as a component of
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Inferred To
IL6R [extracellular region]
(Bos taurus)
IL6R [extracellular region]
(Canis familiaris)
Il6ra [extracellular region]
(Mus musculus)
cb549 [extracellular region]
(Danio rerio)
Ghost homologue of IL6R-2 [extracellular region]
(Sus scrofa)
Ghost homologue of IL6R-2 [extracellular region]
(Xenopus tropicalis)
IL6R-2 [extracellular region]
(Gallus gallus)
Il6r [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_000556.1
,
NP_001193795.1
,
NP_852004.1
Guide to Pharmacology - Targets
1708
OpenTargets
ENSG00000160712
GeneCards
P08887
HPA
ENSG00000160712-IL6R
Ensembl
ENSP00000340589
,
ENSG00000160712
,
ENST00000368485
,
ENSP00000357470
,
ENST00000344086
PRO
P08887
Pharos - Targets
P08887
Orphanet
29643
PDB
8D82
,
2ARW
,
1N26
,
1P9M
,
7DC8
,
5FUC
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05231 IL6
3
IL6 [extracellular region]
(R-HSA-447100)
IL6 [endoplasmic reticulum lumen]
(R-HSA-8956764)
p-IL6 [endoplasmic reticulum lumen]
(R-HSA-8957044)
0.823
7
UniProt:Q92673 SORL1
2
SORL1 [endosome membrane]
(R-HSA-8871475)
SORL1 [Golgi membrane]
(R-HSA-8871510)
0.619
7
UniProt:Q2HRC7 VIL6
0.591
3
UniProt:Q96EQ0 SGTB
0.556
3
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